SCHEMBL8153457

SCHEMBL8153457

Nc1ccc(C(F)(F)F)c(Oc2ccc(C(F)(F)F)c(Oc3c(C(F)(F)F)ccc(N)c3C(F)(F)F)c2)c1C(F)(F)F

nearest known ligand 0.37

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
AR P10275 13/20 0.37
NR4A1 P22736 1/20 0.35
L3MBTL1 Q9Y468 3/20 0.33
RAB9A P51151 1/20 0.33
ALOX5AP P20292 1/20 0.33
FEN1 P39748 1/20 0.33
THRA P10827 1/20 0.33
THRB P10828 1/20 0.33
MAPT P10636 2/20 0.31
LMNA P02545 1/20 0.31
ATM Q13315 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
ALDH1A1 P00352 1/20 0.31
CYP3A4 P08684 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8137329 0.93 AR (0.36) ARNR4A1L3MBTL1RAB9AALOX5AP
SCHEMBL8145304 0.90 AR (0.43) ARNR4A1L3MBTL1RAB9AALOX5AP
SCHEMBL8138749 0.90 AR (0.32) ARL3MBTL1RAB9A
SCHEMBL8151347 0.87 L3MBTL1 (0.35) ARNR4A1L3MBTL1RAB9AALOX5AP
SCHEMBL8151698 0.86 KDM4E (0.33) L3MBTL1THRBMAPTALDH1A1
SCHEMBL8146989 0.85 ALOX5AP (0.38) ARNR4A1L3MBTL1RAB9AALOX5AP
SCHEMBL8147936 0.84 MAPT (0.41) ARNR4A1L3MBTL1ALOX5APFEN1
SCHEMBL8144471 0.83 AR (0.37) ARL3MBTL1RAB9AALOX5APFEN1
SCHEMBL8138338 0.82 L3MBTL1 (0.39) ARNR4A1L3MBTL1RAB9AMAPT
SCHEMBL8152734 0.81 KDM4E (0.31) L3MBTL1RAB9AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6103860-A LOW DIELECTRIC CONSTANT, EXCELLENT TRANSPARENCY, LOW HYGROSCOPICITY AND EXCELLENT PROCESSABILITY; SUBSTRATE FOR AN OPTICAL DISK, A PICK-UP LENS, A PLASTIC SUBSTRATE FOR A LIQUID CELL AND A PRISM MITSUI CHEMICALS, INC. (JP) 2000-08-15 US disclosed
US-5990261-A Organic optical component MITSUI CHEMICALS, INC. (JP) 1999-11-23 US disclosed
EP-0826717-A1 An organic optical component MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1998-03-04 EP disclosed