SCHEMBL8145388

SCHEMBL8145388

Nc1ccc(F)c(Oc2cc(F)c(C(F)(F)F)c(Oc3cc(N)ccc3F)c2C(F)(F)F)c1

nearest known ligand 0.33

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
GLA P06280 1/20 0.33
POLB P06746 1/20 0.33
GAA P10253 1/20 0.33
TSHR P16473 1/20 0.33
KIF11 P52732 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8145739 0.90 POLB (0.32) GLAPOLBGAATSHRKIF11
SCHEMBL8145790 0.83 TSHR (0.35) GLAPOLBGAATSHRKIF11
SCHEMBL8139040 0.82 KIF11 (0.40) GLAPOLBGAATSHRKIF11
SCHEMBL8152749 0.82 MAPT (0.35) GLAPOLBGAATSHRKIF11
SCHEMBL8146875 0.82
SCHEMBL8152832 0.82 GLA (0.33) GLAPOLBGAATSHRKIF11
SCHEMBL8137293 0.81 POLB (0.34) GLAPOLBGAATSHRKIF11
SCHEMBL8147919 0.81 KDM4E (0.30)
SCHEMBL8143574 0.80
SCHEMBL8151334 0.80 TSHR (0.33) GLAPOLBGAATSHRKIF11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6103860-A LOW DIELECTRIC CONSTANT, EXCELLENT TRANSPARENCY, LOW HYGROSCOPICITY AND EXCELLENT PROCESSABILITY; SUBSTRATE FOR AN OPTICAL DISK, A PICK-UP LENS, A PLASTIC SUBSTRATE FOR A LIQUID CELL AND A PRISM MITSUI CHEMICALS, INC. (JP) 2000-08-15 US disclosed
US-5990261-A Organic optical component MITSUI CHEMICALS, INC. (JP) 1999-11-23 US disclosed
EP-0826717-A1 An organic optical component MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1998-03-04 EP disclosed