SCHEMBL8145642

SCHEMBL8145642

Nc1ccc(F)c(Oc2cc(Oc3c(F)ccc(N)c3F)c(C(F)(F)F)c(C(F)(F)F)c2)c1F

nearest known ligand 0.34

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
AR P10275 2/20 0.34
KDM4E B2RXH2 1/20 0.31
MAPT P10636 1/20 0.31
CRHBP P24387 1/20 0.31
CRHR2 Q13324 1/20 0.31
HTR2A P28223 1/20 0.30
SLC6A4 P31645 1/20 0.30
KCNH2 Q12809 1/20 0.30
EPAS1 Q99814 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8145701 0.89 MAPT (0.33) KDM4EMAPTCRHBPCRHR2
SCHEMBL8147207 0.86 AR (0.41) ARKDM4EMAPTCRHBPCRHR2
SCHEMBL8138433 0.84 KIF11 (0.32) ARKDM4EMAPTCRHBPCRHR2
SCHEMBL8145690 0.83 KDM4E (0.36) ARKDM4EMAPTCRHBPCRHR2
SCHEMBL8147224 0.83 KDM4E (0.36) KDM4EMAPTCRHBPCRHR2
SCHEMBL8146655 0.82 AR (0.33) AR
SCHEMBL8138444 0.82 KDM4E (0.32) KDM4EMAPTCRHBPCRHR2
SCHEMBL8138749 0.82 AR (0.32) AR
SCHEMBL8146669 0.81 KDM4E (0.35) KDM4EMAPTCRHBPCRHR2
SCHEMBL8143676 0.80 KDM4E (0.34) KDM4EMAPTCRHBPCRHR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6103860-A LOW DIELECTRIC CONSTANT, EXCELLENT TRANSPARENCY, LOW HYGROSCOPICITY AND EXCELLENT PROCESSABILITY; SUBSTRATE FOR AN OPTICAL DISK, A PICK-UP LENS, A PLASTIC SUBSTRATE FOR A LIQUID CELL AND A PRISM MITSUI CHEMICALS, INC. (JP) 2000-08-15 US disclosed
US-5990261-A Organic optical component MITSUI CHEMICALS, INC. (JP) 1999-11-23 US disclosed
EP-0826717-A1 An organic optical component MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1998-03-04 EP disclosed