Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 2/20 | 0.63 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.63 |
| ▸ | PNP | P00491 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.63 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.45 |
| ▸ | NT5E | P21589 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.41 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8146893 | 1.00 | PDE4D (0.63) | PDE4DPDE3APNPLMNATP53 | |
| SCHEMBL29283551 | 0.82 | ADORA2A (0.64) | PDE4DPDE3APNPLMNATP53 | |
| SCHEMBL29673055 | 0.82 | ADORA2A (0.64) | PDE4DPDE3APNPLMNATP53 | |
| SCHEMBL20419331 | 0.82 | ADORA2A (0.64) | PDE4DPDE3APNPLMNATP53 | |
| SCHEMBL14253676 | 0.82 | ADORA2A (0.64) | PDE4DPDE3APNPLMNATP53 | |
| SCHEMBL24420987 | 0.82 | ADORA2A (0.64) | PDE4DPDE3APNPLMNATP53 | |
| SCHEMBL30366664 | 0.82 | ADORA2A (0.64) | PDE4DPDE3APNPLMNATP53 | |
| SCHEMBL440599 | 0.82 | ADORA2A (0.64) | PDE4DPDE3APNPLMNATP53 | |
| SCHEMBL659995 | 0.82 | ADORA2A (0.64) | PDE4DPDE3APNPLMNATP53 | |
| SCHEMBL14075812 | 0.79 | NADK (0.54) | PDE4DPDE3APNPLMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6147199-A | 2-deoxy-isoguanosines isoteric analogues and isoguanosine containing oligonucleotides | BOEHRINGER MANNHEIM (DE) | 2000-11-14 | — | — | US | disclosed |
| EP-0624161-B1 | 2'-DESOXY-ISOGUANOSINES, ISOSTER ANALOGUES AND ISOGUANOSINE DERIVATES AND THEIR USE | BOEHRINGER MANNHEIM GMBH (DE) | 1999-02-24 | — | — | EP | disclosed |
| EP-0624161-A1 | 2'-DESOXY-ISOGUANOSINES, ISOSTER ANALOGUES AND ISOGUANOSINE DERIVATES AND THEIR USE | Roche Diagnostics GmbH (DE) | 1994-11-17 | — | — | EP | disclosed |
| WO-1993012130-A1 | 2'-DESOXY-ISOGUANOSINES, ISOSTER ANALOGUES AND ISOGUANOSINE DERIVATES AND THEIR USE | BOEHRINGER MANNHEIM GMBH (DE) | 1993-06-24 | — | — | WO | disclosed |