Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 15/20 | 0.66 |
| ▸ | HTR1B | P28222 | 13/20 | 0.66 |
| ▸ | HTR2A | P28223 | 10/20 | 0.66 |
| ▸ | MEN1 | O00255 | 5/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.57 |
| ▸ | TP53 | P04637 | 3/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.57 |
| ▸ | HTR2C | P28335 | 3/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | THPO | P40225 | 2/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8154054 | 0.96 | HTR1D (0.68) | HTR1DHTR1BHTR2AMEN1MAPT | |
| SCHEMBL8816217 | 0.95 | HTR1D (0.62) | HTR1DHTR1BHTR2AMEN1MAPT | |
| SCHEMBL8147927 | 0.83 | HTR1D (0.45) | HTR1DHTR1BHTR2AMEN1MAPT | |
| SCHEMBL7175126 | 0.82 | HTR1D (0.59) | HTR1DHTR1BHTR2AMEN1MAPT | |
| Oxalic Acid SCHEMBL30227183 | 0.81 | HTR1D (0.57) | HTR1DHTR1BHTR2AMEN1MAPT | |
| Oxalic Acid SCHEMBL6925627 | 0.81 | HTR1D (0.57) | HTR1DHTR1BHTR2AMEN1MAPT | |
| SCHEMBL5432776 | 0.80 | HTR1D (0.91) | HTR1DHTR1BHTR2AMEN1MAPT | |
| SCHEMBL8569674 | 0.79 | HTR1D (1.00) | HTR1DHTR1BHTR2AMEN1MAPT | |
| SCHEMBL8389415 | 0.79 | HTR1D (0.72) | HTR1DHTR1BHTR2AMEN1MAPT | |
| SCHEMBL8148935 | 0.78 | HTR1D (0.65) | HTR1DHTR1BHTR2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019412-A1 | BIPHENYL(THIO)AMIDE AND BIPHENYLETHAN(THI)ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS 5-HT 1D? RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2000-07-19 | — | — | EP | claimed |
| US-5972935-A | Biphenyl(thio)amide and bipennylethan(thi) one derivatives, their preparation and their use as 5-HT1D receptor antagonists | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-10-26 | — | — | US | claimed |
| WO-1997007120-A9 | BIPHENYL(THIO)AMIDE AND BIPHENYLETHAN(THI)ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS 5-HT1D RECEPTOR ANTAGONISTS | — | 1997-04-03 | — | — | WO | claimed |
| WO-1997007120-A1 | BIPHENYL(THIO)AMIDE AND BIPHENYLETHAN(THI)ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS 5-HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-02-27 | — | — | WO | claimed |
| EP-1019412-A1 | BIPHENYL(THIO)AMIDE AND BIPHENYLETHAN(THI)ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS 5-HT 1D? RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2000-07-19 | — | — | EP | disclosed |
| US-5972935-A | Biphenyl(thio)amide and bipennylethan(thi) one derivatives, their preparation and their use as 5-HT1D receptor antagonists | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-10-26 | — | — | US | disclosed |
| WO-1997007120-A9 | BIPHENYL(THIO)AMIDE AND BIPHENYLETHAN(THI)ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS 5-HT1D RECEPTOR ANTAGONISTS | — | 1997-04-03 | — | — | WO | disclosed |
| WO-1997007120-A1 | BIPHENYL(THIO)AMIDE AND BIPHENYLETHAN(THI)ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS 5-HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-02-27 | — | — | WO | disclosed |