Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 14/20 | 1.00 |
| ▸ | HTR1B | P28222 | 10/20 | 1.00 |
| ▸ | HTR2A | P28223 | 10/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.59 |
| ▸ | TP53 | P04637 | 3/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.59 |
| ▸ | HTR2C | P28335 | 3/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.59 |
| ▸ | THPO | P40225 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8562908 | 0.95 | HTR1D (0.91) | HTR1DHTR1BHTR2ASLC6A4MEN1 | |
| SCHEMBL8570942 | 0.88 | HTR1D (0.78) | HTR1DHTR1BHTR2ASLC6A4MEN1 | |
| SCHEMBL8564809 | 0.86 | HTR1D (0.75) | HTR1DHTR1BHTR2ASLC6A4MEN1 | |
| SCHEMBL8563220 | 0.85 | HTR1D (0.74) | HTR1DHTR1BHTR2ASLC6A4MEN1 | |
| SCHEMBL8793036 | 0.83 | HTR1D (0.71) | HTR1DHTR1BHTR2ASLC6A4MEN1 | |
| SCHEMBL8154054 | 0.81 | HTR1D (0.68) | HTR1DHTR1BHTR2ASLC6A4MEN1 | |
| SCHEMBL8570855 | 0.80 | HTR1D (0.67) | HTR1DHTR1BHTR2ASLC6A4MEN1 | |
| SCHEMBL8147188 | 0.79 | HTR1D (0.66) | HTR1DHTR1BHTR2ASLC6A4MEN1 | |
| SCHEMBL7935768 | 0.79 | HTR1D (0.65) | HTR1DHTR1BHTR2ASLC6A4MEN1 | |
| SCHEMBL8615160 | 0.78 | HTR1D (0.64) | HTR1DHTR1BHTR2ACYP2D6HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756496-A | Amide derivatives having 5HT1D-antagonist activity | SMITHKLINE BEECHAM P.L.C. (GB) | 1998-05-26 | — | — | US | claimed |
| EP-0496314-B1 | Substituted 1,2,3,4-tetrahydrocyclopent[b]indoles, 1,2,3,3a,4,8a-hexahydrocyclopent[b]indoles and related compounds, intermediates and a process for the preparation thereof and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1997-10-01 | — | — | EP | claimed |
| US-5756496-A | Amide derivatives having 5HT1D-antagonist activity | SMITHKLINE BEECHAM P.L.C. (GB) | 1998-05-26 | — | — | US | disclosed |
| EP-0763034-A1 | AMIDE DERIVATIVES HAVING 5HT1D-ANTAGONIST ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1997-03-19 | — | — | EP | disclosed |
| WO-1995032967-A1 | AMIDE DERIVATIVES HAVING 5HT1D-ANTAGONIST ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1995-12-07 | — | — | WO | disclosed |