Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 10/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 10/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 9/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 9/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 9/20 | 0.46 |
| ▸ | F10 | P00742 | 6/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | GRM2 | Q14416 | 10/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8146227 | 0.92 | ITGB3 (0.45) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL8138221 | 0.89 | ITGB3 (0.41) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL8144596 | 0.88 | GRM2 (0.44) | GRM2 | |
| SCHEMBL8137990 | 0.87 | GRM2 (0.45) | GRM2 | |
| SCHEMBL8145258 | 0.82 | GRM2 (0.45) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL8151830 | 0.82 | ITGB3 (0.47) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL8145603 | 0.82 | ITGB3 (0.46) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL8153009 | 0.81 | F10 (0.42) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL8152496 | 0.81 | GRM2 (0.49) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL8137355 | 0.81 | ITGB3 (0.49) | ITGB3ITGA2BPRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6028090-A | Adhesion receptor antagonists III | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-02-22 | — | — | US | disclosed |
| US-5723480-A | Adhesion receptor antagonists III | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-03-03 | — | — | US | disclosed |
| US-5561148-A | Adhesion receptor antagonists III | MERCK PATENT GESELLSCHAFT MIT BESHRANKTER HAFTUNG (DE) | 1996-10-01 | — | — | US | disclosed |
| EP-0645376-A1 | Substituted 1-phenyl-oxazolidin-2-one derivatives, their preparation and their use as adhesion-receptor antagonists | MERCK PATENT GmbH (DE) | 1995-03-29 | — | — | EP | disclosed |