Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8147386 | 1.00 | HDAC3 (0.47) | HDAC3HDAC1HDAC2HDAC8ADORA3 | |
| SCHEMBL8152427 | 0.91 | PTGDR2 (0.43) | HDAC3HDAC1HDAC2HDAC8KDM4E | |
| SCHEMBL8152428 | 0.91 | PTGDR2 (0.43) | HDAC3HDAC1HDAC2HDAC8KDM4E | |
| SCHEMBL8157821 | 0.83 | MEN1 (0.43) | FLT3LMNAPTGDR2KMT2ANPC1 | |
| SCHEMBL8157823 | 0.83 | MEN1 (0.43) | FLT3LMNAPTGDR2KMT2ANPC1 | |
| SCHEMBL8159020 | 0.83 | HDAC3 (0.38) | HDAC3HDAC1HDAC2HDAC8KDM4E | |
| SCHEMBL8159022 | 0.83 | HDAC3 (0.38) | HDAC3HDAC1HDAC2HDAC8KDM4E | |
| SCHEMBL8158980 | 0.80 | HPGD (0.47) | KDM4ELMNAKMT2A | |
| SCHEMBL8158984 | 0.80 | HPGD (0.47) | KDM4ELMNAKMT2A | |
| SCHEMBL8130779 | 0.80 | CDK2 (0.41) | ADORA3CDK2FLT3KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019380-A2 | TRICYCLIC 3-OXO-PROPANENITRILE COMPOUNDS | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-07-19 | — | — | EP | disclosed |
| WO-1999016753-A2 | TRICYCLIC 3-OXO-PROPANENITRILE COMPOUNDS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-04-08 | — | — | WO | disclosed |