Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.39 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8158984 | 1.00 | HPGD (0.47) | HPGDALDH1A1POLBPKMPLIN1 | |
| SCHEMBL8152427 | 0.85 | PTGDR2 (0.43) | ALDH1A1MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL8152428 | 0.85 | PTGDR2 (0.43) | ALDH1A1MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL8062450 | 0.84 | HPGD (0.52) | HPGDALDH1A1POLBPKMPLIN1 | |
| SCHEMBL8061390 | 0.83 | HPGD (0.51) | HPGDALDH1A1POLBPKMPLIN1 | |
| SCHEMBL8061393 | 0.83 | HPGD (0.51) | HPGDALDH1A1POLBPKMPLIN1 | |
| SCHEMBL8061388 | 0.83 | HPGD (0.51) | HPGDALDH1A1POLBPKMPLIN1 | |
| SCHEMBL8157821 | 0.80 | MEN1 (0.43) | ALDH1A1LMNAMEN1KMT2AGAA | |
| SCHEMBL8147386 | 0.80 | HDAC3 (0.47) | LMNAKMT2AKDM4E | |
| SCHEMBL8147388 | 0.80 | HDAC3 (0.47) | LMNAKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019380-A2 | TRICYCLIC 3-OXO-PROPANENITRILE COMPOUNDS | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-07-19 | — | — | EP | disclosed |
| WO-1999016753-A2 | TRICYCLIC 3-OXO-PROPANENITRILE COMPOUNDS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-04-08 | — | — | WO | disclosed |