SCHEMBL8147646

SCHEMBL8147646

CCOC(=O)Cc1cccc(OCCCl)c1

nearest known ligand 0.53

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 4/20 0.53
MAPK1 P28482 3/20 0.53
TDP1 Q9NUW8 3/20 0.53
TSHR P16473 2/20 0.53
PPARA Q07869 2/20 0.51
PPARG P37231 1/20 0.51
MAOB P27338 2/20 0.47
PLA2G4B P0C869 1/20 0.45
F10 P00742 1/20 0.45
ALDH1A1 P00352 1/20 0.44
POLB P06746 1/20 0.43
AR P10275 1/20 0.43
CYP2D6 P10635 2/20 0.42
TBXAS1 P24557 1/20 0.42
LTA4H P09960 1/20 0.41
LTB4R Q15722 1/20 0.41
LTB4R2 Q9NPC1 1/20 0.41
CYSLTR2 Q9NS75 1/20 0.41
CYSLTR1 Q9Y271 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7041814 0.94 L3MBTL1 (0.54) L3MBTL1MAPK1TDP1TSHRPPARA
SCHEMBL31285834 0.87 PPARA (0.57) L3MBTL1MAPK1TDP1TSHRPPARA
SCHEMBL2008583 0.87 PPARA (0.57) L3MBTL1MAPK1TDP1TSHRPPARA
SCHEMBL7397992 0.86 L3MBTL1 (0.53) L3MBTL1MAPK1TDP1TSHRPPARA
SCHEMBL2768717 0.86 SLC7A5 (0.48) L3MBTL1MAPK1TDP1TSHRPLA2G4B
SCHEMBL27855936 0.85 L3MBTL1 (0.53) L3MBTL1MAPK1TDP1TSHRPPARA
SCHEMBL27855922 0.84 L3MBTL1 (0.55) L3MBTL1MAPK1TDP1TSHRPPARA
SCHEMBL27356055 0.84 MAPK1 (0.55) L3MBTL1MAPK1TDP1TSHRPPARA
SCHEMBL8147320 0.83 PPARA (0.56) L3MBTL1MAPK1TDP1TSHRPPARA
SCHEMBL27855926 0.83 L3MBTL1 (0.54) L3MBTL1MAPK1TDP1TSHRPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6041157-A Environmentally sensitive compositions of matter based on 3H-fluoren-3-ylidenes and process for making same GOETZ FREDERICK JAMES (US) 2000-03-21 US disclosed