Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 4/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | TTK | P33981 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | ITK | Q08881 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | BCR | P11274 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8148939 | 0.97 | ULK1 (0.44) | ULK1AURKATTKPDPK1BRD4 | |
| SCHEMBL5906358 | 0.89 | NPC1 (0.41) | ULK1PDPK1ABL1BCRFGFR1 | |
| SCHEMBL5309301 | 0.87 | JAK2 (0.53) | ULK1AURKABRD4ITKJAK2 | |
| SCHEMBL5306459 | 0.85 | HTR1D (0.42) | AURKATTKBRD4 | |
| SCHEMBL8713578 | 0.83 | SLC6A4 (0.52) | — | |
| SCHEMBL5906388 | 0.83 | JAK2 (0.36) | ULK1TTKPDPK1ABL1BCR | |
| SCHEMBL5302823 | 0.83 | JAK2 (0.43) | ULK1AURKAITKABL1BCR | |
| SCHEMBL5312586 | 0.83 | KDR (0.42) | PDPK1ITKABL1BCRFGFR1 | |
| SCHEMBL5311332 | 0.82 | JAK2 (0.56) | ULK1ABL1BCRJAK2JAK1 | |
| SCHEMBL5311677 | 0.82 | JAK2 (0.55) | ULK1AURKABRD4ITKJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000006173-A1 | 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |