Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 2/20 | 0.40 |
| ▸ | MMP9 | P14780 | 2/20 | 0.40 |
| ▸ | MMP12 | P39900 | 2/20 | 0.40 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.39 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CTRC | Q99895 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | NAAA | Q02083 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15302651 | 0.85 | CA12 (0.43) | MMP2MMP9MMP12CYSLTR2CYSLTR1 | |
| SCHEMBL15302252 | 0.85 | CA12 (0.43) | MMP2MMP9MMP12CYSLTR2CYSLTR1 | |
| SCHEMBL11723473 | 0.85 | CA12 (0.43) | MMP2MMP9MMP12CYSLTR2CYSLTR1 | |
| SCHEMBL11755095 | 0.85 | CA12 (0.43) | MMP2MMP9MMP12CYSLTR2CYSLTR1 | |
| SCHEMBL504148 | 0.80 | MMP12 (0.44) | MMP2MMP9MMP12CYSLTR2CYSLTR1 | |
| SCHEMBL8669192 | 0.76 | BID (0.47) | CYSLTR2CYSLTR1ALDH1A1MAPTNAAA | |
| SCHEMBL11291328 | 0.76 | CYSLTR2 (0.45) | CYSLTR2CYSLTR1ALDH1A1MAPT | |
| SCHEMBL9620287 | 0.76 | PPARG (0.49) | CYSLTR2CYSLTR1ALDH1A1MAPTNAAA | |
| SCHEMBL11295816 | 0.76 | CYSLTR2 (0.45) | CYSLTR2CYSLTR1ALDH1A1MAPT | |
| SCHEMBL8663792 | 0.76 | BID (0.47) | CYSLTR2CYSLTR1ALDH1A1MAPTNAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0763524-B1 | Urea and amide derivatives having ACAT inhibitory activity, their preparation and their therapeutic and prophylactic use | SANKYO CO (JP) | 2000-08-23 | — | — | EP | disclosed |
| EP-0763524-A1 | Urea and amide derivatives having ACAT inhibitory activity, their preparation and their therapeutic and prophylactic use | SANKYO COMPANY LIMITED (JP) | 1997-03-19 | — | — | EP | disclosed |