Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 3/20 | 0.40 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.34 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CA3 | P07451 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21550525 | 0.83 | HDAC1 (0.36) | TTRHDAC1HDAC6CA1CA2 | |
| SCHEMBL8148621 | 0.82 | TTR (0.48) | TTRAKR1C2AKR1C1AKR1C4AKR1C3 | |
| SCHEMBL29133203 | 0.81 | TTR (0.47) | TTRAKR1C2AKR1C1AKR1C4AKR1C3 | |
| SCHEMBL24558455 | 0.80 | KMT2A (0.35) | TTRHDAC1HDAC6CA1CA2 | |
| SCHEMBL30929295 | 0.80 | KMT2A (0.35) | TTRHDAC1HDAC6CA1CA2 | |
| SCHEMBL23655038 | 0.77 | TTR (0.47) | TTRAKR1C2AKR1C1AKR1C4AKR1C3 | |
| SCHEMBL31426608 | 0.76 | CA1 (0.37) | HDAC1HDAC6CA1CA2CA9 | |
| SCHEMBL17541094 | 0.76 | CA1 (0.41) | TTRHDAC1HDAC6CA1CA2 | |
| SCHEMBL31728878 | 0.75 | ALDH1A1 (0.37) | AKR1C2AKR1C1CA1CA2TDP1 | |
| SCHEMBL20396360 | 0.75 | TTR (0.48) | TTRAKR1C2AKR1C1AKR1C4AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0686145-B1 | NEW COMPOUNDS | UNIV MARYLAND (US) | 2000-01-26 | — | — | EP | disclosed |
| US-5883129-A | Hydroxylated anthranilic acid derivatives | ASTRA AKTIEBOLAG (SE) | 1999-03-16 | — | — | US | disclosed |
| US-5523475-A | New compounds | AKTIEBOLAGET ASTRA (SE) | 1996-06-04 | — | — | US | disclosed |
| CN-1121345-A | New compounds | ASTRA AB (SE) | 1996-04-24 | — | — | CN | disclosed |
| EP-0686145-A1 | NEW COMPOUNDS | AKTIEBOLAGET ASTRA (SE) | 1995-12-13 | — | — | EP | disclosed |
| WO-1994019316-A1 | NEW COMPOUNDS | AKTIEBOLAGET ASTRA (SE) | 1994-09-01 | — | — | WO | disclosed |