Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.63 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | PPARG | P37231 | 3/20 | 0.61 |
| ▸ | NR2E3 | Q9Y5X4 | 3/20 | 0.61 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ADK | P55263 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TOP1 | P11387 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2039851 | 0.82 | HPGD (0.89) | HPGDPTK2BCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8148584 | 0.77 | HPGD (0.40) | HPGDPTK2BCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL2049699 | 0.76 | ADK (0.58) | HPGDPTK2BCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL2037291 | 0.76 | HPGD (0.79) | HPGDPTK2BCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8154479 | 0.74 | PSD (0.47) | HPGDMCL1POLBADKKMT2A | |
| SCHEMBL8152909 | 0.71 | ADK (0.52) | HPGDPTK2BCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL2035586 | 0.71 | HPGD (0.77) | HPGDPTK2BCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8146519 | 0.71 | CYP1A2 (0.45) | HPGDPTK2BCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8152829 | 0.70 | ADK (0.53) | HPGDPPARGNR2E3NCOR2KDM4E | |
| SCHEMBL8140762 | 0.69 | PPARG (0.76) | HPGDPTK2BCYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0989986-A1 | 5,7-DISUBSTITUTED 4-AMINOPYRIDO 2,3-D]PYRIMIDINE COMPOUNDS AND THEIR USE AS ADENOSINE KINASE INHIBITORS | Abbott Laboratories (US) | 2000-04-05 | — | — | EP | claimed |
| WO-1998046605-A1 | 5,7-DISUBSTITUTED 4-AMINOPYRIDO[2,3-D]PYRIMIDINE COMPOUNDS AND THEIR USE AS ADENOSINE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 1998-10-22 | — | — | WO | claimed |