Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 5/20 | 1.00 |
| ▸ | HTR1B | P28222 | 3/20 | 1.00 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8148463 | 0.80 | HTR1D (0.67) | HTR1DHTR1BPOLBGABRA1GABRB2 | |
| SCHEMBL15088033 | 0.74 | HTR1D (0.59) | HTR1DHTR1BPOLBGABRA1GABRB2 | |
| SCHEMBL2687552 | 0.73 | HTR1D (0.58) | HTR1DHTR1BPOLBMAPTCYP3A4 | |
| SCHEMBL11441560 | 0.72 | HTR1D (0.56) | HTR1DHTR1BPOLBGABRA1GABRB2 | |
| SCHEMBL11223055 | 0.72 | HTR1D (0.68) | HTR1DHTR1BPOLBGABRA1GABRB2 | |
| SCHEMBL2700476 | 0.69 | HTR1D (0.53) | HTR1DHTR1BLMNAMAPTALDH1A1 | |
| SCHEMBL3622094 | 0.68 | HTR1D (0.57) | HTR1DHTR1BPOLBGABRA1GABRB2 | |
| SCHEMBL3297389 | 0.67 | HTR1D (0.50) | HTR1DHTR1BPOLBLMNATSHR | |
| SCHEMBL14959898 | 0.67 | HTR1D (0.56) | HTR1DHTR1BPOLBGABRA1GABRB2 | |
| SCHEMBL2989162 | 0.67 | HTR1D (0.56) | HTR1DHTR1BPOLBGABRA1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6048862-A | Benzylamidine derivatives with serotonin receptor binding activity | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2000-04-11 | — | — | US | claimed |
| US-6048862-A | Benzylamidine derivatives with serotonin receptor binding activity | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2000-04-11 | — | — | US | disclosed |
| US-5969137-A | TREATMENT OF NERVOUS SYSTEM DISORDERS | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1999-10-19 | — | — | US | disclosed |