Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 2/20 | 0.32 |
| ▸ | MMP3 | P08254 | 2/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8133660 | 0.93 | PLA2G4B (0.39) | MEN1KMT2AEGFRPPARG | |
| SCHEMBL8122551 | 0.92 | KMT2A (0.35) | MEN1KMT2AEGFRPPARGSMPD1 | |
| SCHEMBL8133459 | 0.92 | MAPK1 (0.38) | HDAC1HDAC8HDAC6PLK1SMPD1 | |
| SCHEMBL8149894 | 0.91 | MAPK1 (0.34) | PPARGHDAC1HDAC8HDAC6PLK1 | |
| SCHEMBL8135122 | 0.91 | HDAC1 (0.40) | MEN1KMT2AHDAC1HDAC8HDAC6 | |
| SCHEMBL8140437 | 0.90 | HDAC1 (0.35) | HDAC1HDAC8HDAC6PLK1SMPD1 | |
| SCHEMBL8148216 | 0.89 | LPAR1 (0.41) | HDAC1HDAC8HDAC6PLK1MAPK1 | |
| SCHEMBL8134646 | 0.89 | LPAR1 (0.40) | HDAC1HDAC8HDAC6PLK1MMP1 | |
| SCHEMBL8142291 | 0.88 | HDAC1 (0.35) | MEN1KMT2AHDAC1HDAC8HDAC6 | |
| SCHEMBL8148224 | 0.87 | ALDH1A1 (0.38) | HDAC1HDAC8HDAC6SMPD1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0763524-B1 | Urea and amide derivatives having ACAT inhibitory activity, their preparation and their therapeutic and prophylactic use | SANKYO CO (JP) | 2000-08-23 | — | — | EP | disclosed |
| US-6040339-A | TREATMENT AND PROPHYLAXIS OF HYPERCHOLESTEREMIA OR ARTERIOSCLEROSIS IN A MAMMAL | SANKYO COMPANY, LIMITED (JP) | 2000-03-21 | — | — | US | disclosed |
| EP-0763524-A1 | Urea and amide derivatives having ACAT inhibitory activity, their preparation and their therapeutic and prophylactic use | SANKYO COMPANY LIMITED (JP) | 1997-03-19 | — | — | EP | disclosed |