Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 5/20 | 0.49 |
| ▸ | PDE4A | P27815 | 2/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13709019 | 0.89 | MAPT (0.40) | PDE4BPDE4APDE4CPDE4DSIGMAR1 | |
| SCHEMBL10841129 | 0.87 | SLC6A2 (0.49) | PDE4BPDE4APDE4CPDE4DSLC6A3 | |
| SCHEMBL5451966 | 0.87 | PDE4B (0.51) | PDE4B | |
| SCHEMBL6694605 | 0.87 | PDE4B (0.51) | PDE4B | |
| SCHEMBL15144418 | 0.87 | PDE4B (0.51) | PDE4B | |
| SCHEMBL6694614 | 0.87 | PDE4B (0.51) | PDE4B | |
| SCHEMBL12602246 | 0.87 | PDE4B (0.51) | PDE4B | |
| SCHEMBL3065548 | 0.87 | PDE4B (0.51) | PDE4B | |
| SCHEMBL951033 | 0.87 | PDE4B (0.51) | PDE4B | |
| SCHEMBL1105737 | 0.86 | KMT2A (0.48) | PDE4BPDE4APDE4CPDE4DSLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6066737-A | Process for the preparation of optically enriched 4-aryl-3-hydromethyl substituted piperidines to be used as intermediates in the synthesis of paroxetine | CHIROTECH TECHNOLOGY, LTD. (GB) | 2000-05-23 | — | — | US | disclosed |