Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OTC | P00480 | 1/20 | 0.44 |
| ▸ | DDAH1 | O94760 | 3/20 | 0.42 |
| ▸ | GSR | P00390 | 2/20 | 0.41 |
| ▸ | NOS2 | P35228 | 6/20 | 0.40 |
| ▸ | NOS3 | P29474 | 5/20 | 0.40 |
| ▸ | NOS1 | P29475 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | GRM8 | O00222 | 1/20 | 0.36 |
| ▸ | GRM6 | O15303 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL355180 | 1.00 | OTC (0.44) | OTCDDAH1GSRNOS2NOS3 | |
| Arginine SCHEMBL15740622 | 1.00 | OTC (0.44) | OTCDDAH1GSRNOS2NOS3 | |
| Arginine SCHEMBL29191149 | 0.95 | OTC (0.41) | OTCDDAH1GSRNOS2NOS3 | |
| Arginine SCHEMBL6946785 | 0.94 | OTC (0.49) | OTCDDAH1GSRNOS2NOS3 | |
| Arginine SCHEMBL263652 | 0.94 | OTC (0.49) | OTCDDAH1GSRNOS2NOS3 | |
| Arginine SCHEMBL288809 | 0.94 | OTC (0.49) | OTCDDAH1GSRNOS2NOS3 | |
| Arginine SCHEMBL1898345 | 0.94 | OTC (0.49) | OTCDDAH1GSRNOS2NOS3 | |
| Arginine SCHEMBL5698936 | 0.94 | OTC (0.49) | OTCDDAH1GSRNOS2NOS3 | |
| Arginine SCHEMBL20946267 | 0.94 | OTC (0.49) | OTCDDAH1GSRNOS2NOS3 | |
| Arginine SCHEMBL453745 | 0.94 | OTC (0.49) | OTCDDAH1GSRNOS2NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6074871-A | BIOREACTOR FOR PROPAGATION OF CELLS; FOR EVALUATION OF CANCER CELLS; FOR RECOVERY OF BIOLOGICAL PRODUCTS | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF THE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION (US) | 2000-06-13 | — | — | US | disclosed |
| EP-0744614-B1 | Use of Isoelectric point markers for isoelectric focusing with fluorescence detection | LAB MOLECULAR BIOPHOTONICS (JP) | 1999-12-22 | — | — | EP | disclosed |
| US-5939314-A | USEFUL FOR CONTACT LENSES, DERSSINGS FOR ENHANCING SKIN HEALING, MEMBRANES FOR BLOOD DIALYSIS, PROSTHETIC FOR VASUCLAR OR SKELETAL SYSTEM, ARTIFICIAL ORGANS, IMPLANTS FOR RECONSTRUCTIVE COSMETIC SURGERY | THE UNITED STATES OF AMERICA AS REPRESENTED THE ADMINISTRATOR OF THE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION (US) | 1999-08-17 | — | — | US | disclosed |
| US-5935845-A | POROUS POLYSILOXANE CAN BE EFFECTIVELY TRATED AND MADE HYDROPHILIC BY EXPOSURE TO ATOMIC OXYGEN | THE UNITED STATES OF AMERICA AS REPRESENTED BY THEADMINISTRATOR, NATIONAL AERONAUTICS AND SPACE ADMINISTRATION (US) | 1999-08-10 | — | — | US | disclosed |
| US-5866683-A | Isoelectric point markers for isoelectric focusing with fluorescence detection | LABORATORY OF MOLECULAR BIOPHOTONICS (JP) | 1999-02-02 | — | — | US | disclosed |
| US-5798261-A | SURFACE-MODIFIED WITH GAS PHASE RADICALS TO PRODUCE HYDROPHOBIC AND HYDROPHILIC REGIONS | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF THE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION (US) | 1998-08-25 | — | — | US | disclosed |
| EP-0744614-A2 | Isoelectric point markers for isoelectric focusing with fluorescence detection | Laboratory of Molecular Biophotonics (JP) | 1996-11-27 | — | — | EP | disclosed |
| US-5369012-A | Method of making a membrane having hydrophilic and hydrophobic surfaces for adhering cells or antibodies by using atomic oxygen or hydroxyl radicals | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF THE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION (US) | 1994-11-29 | — | — | US | disclosed |