SCHEMBL8150996

SCHEMBL8150996

[CH]=Cc1cc2ccccc2cn1

nearest known ligand 0.48

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.48
CYP2A6 P11509 1/20 0.48
PDPK1 O15530 1/20 0.48
NPC1 O15118 2/20 0.40
PLAU P00749 1/20 0.40
RAB9A P51151 1/20 0.38
HTR3A P46098 1/20 0.37
KDM4E B2RXH2 2/20 0.36
ATM Q13315 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
BTK Q06187 1/20 0.36
NQO2 P16083 1/20 0.34
GPR3 P46089 1/20 0.34
MAPT P10636 2/20 0.34
CHEK1 O14757 1/20 0.34
PDGFRB P09619 1/20 0.32
PDGFRA P16234 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29956635 0.78 CYP2A6 (0.48) CYP1A2CYP2A6PDPK1NPC1PLAU
SCHEMBL1202061 0.78 CYP2A6 (0.48) CYP1A2CYP2A6PDPK1NPC1PLAU
SCHEMBL2338713 0.78 CYP1A2 (0.48) CYP1A2CYP2A6PDPK1NPC1PLAU
SCHEMBL28318632 0.77 CYP2A6 (0.47) CYP1A2CYP2A6PDPK1NPC1PLAU
SCHEMBL6157317 0.75 CYP1A2 (0.45) CYP1A2CYP2A6PDPK1NPC1PLAU
SCHEMBL6157320 0.75 CYP1A2 (0.45) CYP1A2CYP2A6PDPK1NPC1PLAU
SCHEMBL12408769 0.75 CYP1A2 (0.50) CYP1A2CYP2A6PDPK1NPC1PLAU
SCHEMBL3163853 0.74 KDM4E (0.60) CYP1A2CYP2A6PDPK1NPC1RAB9A
SCHEMBL3163852 0.74 KDM4E (0.60) CYP1A2CYP2A6PDPK1NPC1RAB9A
SCHEMBL8719613 0.74 NPC1 (0.50) CYP1A2CYP2A6PDPK1NPC1PLAU

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0944594-A4 INHIBITORS OF THE ENZYMATIC ACTIVITY OF PSA LILLY CO ELI (US) 2000-05-03 EP disclosed
EP-0944594-A1 INHIBITORS OF THE ENZYMATIC ACTIVITY OF PSA ELI LILLY AND COMPANY (US) 1999-09-29 EP disclosed
WO-1998025895-A1 INHIBITORS OF THE ENZYMATIC ACTIVITY OF PSA ELI LILLY AND COMPANY (US) 1998-06-18 WO disclosed