Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6157317 | 1.00 | CYP1A2 (0.45) | CYP1A2CYP2A6PDPK1NPC1PLAU | |
| SCHEMBL22147967 | 0.81 | CYP1A2 (0.42) | CYP1A2CYP2A6PDPK1NPC1PLAU | |
| SCHEMBL12408769 | 0.80 | CYP1A2 (0.50) | CYP1A2CYP2A6PDPK1NPC1PLAU | |
| SCHEMBL2338713 | 0.79 | CYP1A2 (0.48) | CYP1A2CYP2A6PDPK1NPC1PLAU | |
| SCHEMBL3163853 | 0.78 | KDM4E (0.60) | CYP1A2CYP2A6PDPK1NPC1RAB9A | |
| SCHEMBL3163852 | 0.78 | KDM4E (0.60) | CYP1A2CYP2A6PDPK1NPC1RAB9A | |
| SCHEMBL11386648 | 0.76 | CYP1A2 (0.46) | CYP1A2CYP2A6PDPK1NPC1PLAU | |
| SCHEMBL11386650 | 0.76 | CYP1A2 (0.46) | CYP1A2CYP2A6PDPK1NPC1PLAU | |
| SCHEMBL1202061 | 0.75 | CYP2A6 (0.48) | CYP1A2CYP2A6PDPK1NPC1PLAU | |
| SCHEMBL8150996 | 0.75 | CYP1A2 (0.48) | CYP1A2CYP2A6PDPK1NPC1PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6933283-B2 | 11-deoxy azalide antibacterials | ABBOTT LABORATORIES (US) | 2005-08-23 | — | — | US | claimed |
| EP-1501847-A2 | 11-DEOXY AZALIDE ANTIBACTERIALS | Abbott Laboratories (US) | 2005-02-02 | — | — | EP | claimed |
| US-20040014953-A1 | 11-Deoxy azalide antibacterials | ABBVIE INC. | 2004-01-22 | — | — | US | claimed |
| WO-2003090679-A2 | 11-DEOXY AZALIDE ANTIBACTERIALS | ABBOTT LABORATORIES (US) | 2003-11-06 | — | — | WO | claimed |
| US-6933283-B2 | 11-deoxy azalide antibacterials | ABBOTT LABORATORIES (US) | 2005-08-23 | — | — | US | disclosed |
| EP-1501847-A2 | 11-DEOXY AZALIDE ANTIBACTERIALS | Abbott Laboratories (US) | 2005-02-02 | — | — | EP | disclosed |
| US-20040014953-A1 | 11-Deoxy azalide antibacterials | ABBVIE INC. | 2004-01-22 | — | — | US | disclosed |
| WO-2003090679-A2 | 11-DEOXY AZALIDE ANTIBACTERIALS | ABBOTT LABORATORIES (US) | 2003-11-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040014953-A1 | 11-Deoxy azalide antibacterials | TOP1, TOP2B, TOP2A | CYP1A2 166/4885CYP2A6 179/4885PDPK1 3313/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.