SCHEMBL8151369

SCHEMBL8151369

Nc1cccc(Oc2ccc(C(F)(F)F)c(Oc3cccc(N)c3F)c2F)c1F

nearest known ligand 0.46

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.46
KDM4E B2RXH2 1/20 0.46
CRHBP P24387 1/20 0.46
CRHR2 Q13324 1/20 0.46
NPSR1 Q6W5P4 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
CYP1A2 P05177 1/20 0.31
CYP3A4 P08684 1/20 0.31
CYP2C19 P33261 1/20 0.31
MPL P40238 2/20 0.31
AR P10275 2/20 0.30
IDO1 P14902 1/20 0.30
TDO2 P48775 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8151393 0.90 MAPT (0.42) MAPTKDM4ECRHBPCRHR2NPSR1
SCHEMBL8146953 0.90 MAPT (0.42) MAPTKDM4ECRHBPCRHR2NPSR1
SCHEMBL8139263 0.86 MAPT (0.47) MAPTKDM4ECRHBPCRHR2NPSR1
SCHEMBL8150915 0.85 KDM4E (0.38) MAPTKDM4ECRHBPCRHR2L3MBTL1
SCHEMBL8138120 0.82 KDM4E (0.34) MAPTKDM4ECRHBPCRHR2
SCHEMBL8138947 0.82 MAPT (0.44) MAPTKDM4ECRHBPCRHR2NPSR1
SCHEMBL8146688 0.82 EPAS1 (0.35) MAPTKDM4ECRHBPCRHR2L3MBTL1
SCHEMBL8147692 0.81 MAPT (0.41) MAPTKDM4ECRHBPCRHR2NPSR1
SCHEMBL8323909 0.81 L3MBTL1 (0.38) MAPTKDM4ECRHBPCRHR2NPSR1
SCHEMBL8146743 0.80 KDM4E (0.34) MAPTKDM4ECRHBPCRHR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6103860-A LOW DIELECTRIC CONSTANT, EXCELLENT TRANSPARENCY, LOW HYGROSCOPICITY AND EXCELLENT PROCESSABILITY; SUBSTRATE FOR AN OPTICAL DISK, A PICK-UP LENS, A PLASTIC SUBSTRATE FOR A LIQUID CELL AND A PRISM MITSUI CHEMICALS, INC. (JP) 2000-08-15 US disclosed
US-5990261-A Organic optical component MITSUI CHEMICALS, INC. (JP) 1999-11-23 US disclosed
EP-0826717-A1 An organic optical component MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1998-03-04 EP disclosed