Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 15/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 5/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 5/20 | 0.44 |
| ▸ | F10 | P00742 | 3/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8145258 | 0.90 | GRM2 (0.45) | GRM2ITGB3PRSS1PRSS2ITGA2B | |
| SCHEMBL8152303 | 0.87 | GRM2 (0.50) | GRM2 | |
| SCHEMBL8152623 | 0.87 | GRM2 (0.45) | GRM2ITGB3PRSS1PRSS2ITGA2B | |
| SCHEMBL8138934 | 0.85 | GRM2 (0.53) | GRM2 | |
| SCHEMBL8151833 | 0.85 | GRM2 (0.52) | GRM2ITGB3PRSS1PRSS2ITGA2B | |
| SCHEMBL8151677 | 0.84 | GRM2 (0.57) | GRM2ITGB3PRSS1PRSS2ITGA2B | |
| SCHEMBL8306311 | 0.83 | GRM2 (0.50) | GRM2ITGB3PRSS1PRSS2ITGA2B | |
| SCHEMBL8146333 | 0.83 | GRM2 (0.61) | GRM2ITGB3PRSS1PRSS2ITGA2B | |
| SCHEMBL8146616 | 0.83 | GRM2 (0.49) | GRM2ITGB3PRSS1PRSS2ITGA2B | |
| SCHEMBL8146227 | 0.82 | ITGB3 (0.45) | GRM2ITGB3PRSS1PRSS2ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6028090-A | Adhesion receptor antagonists III | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-02-22 | — | — | US | disclosed |
| US-5723480-A | Adhesion receptor antagonists III | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-03-03 | — | — | US | disclosed |
| US-5561148-A | Adhesion receptor antagonists III | MERCK PATENT GESELLSCHAFT MIT BESHRANKTER HAFTUNG (DE) | 1996-10-01 | — | — | US | disclosed |
| EP-0645376-A1 | Substituted 1-phenyl-oxazolidin-2-one derivatives, their preparation and their use as adhesion-receptor antagonists | MERCK PATENT GmbH (DE) | 1995-03-29 | — | — | EP | disclosed |