Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10794534 | 0.91 | PDGFRB (0.48) | HPGDMAPTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL13905046 | 0.86 | HPGD (0.50) | HPGDMAPTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL6543923 | 0.85 | PDGFRB (0.50) | MAPTCYP2C19L3MBTL1MEN1KMT2A | |
| SCHEMBL27146321 | 0.84 | PDGFRB (0.43) | HPGDMAPTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL27836447 | 0.84 | PDGFRB (0.43) | HPGDMAPTCYP1A2CYP3A4CYP2C9 | |
| Ethylene SCHEMBL7406931 | 0.81 | HPGD (0.46) | HPGDMAPTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL16154026 | 0.81 | HPGD (0.50) | HPGDMAPTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7512069 | 0.81 | HPGD (0.45) | HPGDMAPTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8217655 | 0.80 | ALDH1A1 (0.52) | HPGDMAPTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4516202 | 0.80 | HPGD (0.48) | HPGDMAPTCYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1062216-A1 | INHIBITORS OF PHOSPHOLIPASE A2 | GENETICS INSTITUTE, INC. (US) | 2000-12-27 | — | — | EP | disclosed |
| WO-1999043672-A1 | INHIBITORS OF PHOSPHOLIPASE A2 | GENETICS INSTITUTE, INC. (US) | 1999-09-02 | — | — | WO | disclosed |