SCHEMBL8151983

SCHEMBL8151983

Nc1c(F)c(F)c(F)c(Oc2cc(F)c(C(F)(F)F)c(Oc3c(F)c(N)c(F)c(F)c3F)c2F)c1F

nearest known ligand 0.34

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.34
MAPT P10636 1/20 0.34
CRHBP P24387 1/20 0.34
CRHR2 Q13324 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8152404 0.91 KDM4E (0.31) KDM4EMAPTCRHBPCRHR2
SCHEMBL8152772 0.91 KDM4E (0.34) KDM4EMAPTCRHBPCRHR2
SCHEMBL8146593 0.87 KDM4E (0.33) KDM4EMAPTCRHBPCRHR2
SCHEMBL8144351 0.85
SCHEMBL8145748 0.84
SCHEMBL8151547 0.83 KDM4E (0.30) KDM4EMAPTCRHBPCRHR2
SCHEMBL8138455 0.83 KDM4E (0.33) KDM4EMAPTCRHBPCRHR2
SCHEMBL8146226 0.82
SCHEMBL8137339 0.82
SCHEMBL8151724 0.82 KDM4E (0.34) KDM4EMAPTCRHBPCRHR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6103860-A LOW DIELECTRIC CONSTANT, EXCELLENT TRANSPARENCY, LOW HYGROSCOPICITY AND EXCELLENT PROCESSABILITY; SUBSTRATE FOR AN OPTICAL DISK, A PICK-UP LENS, A PLASTIC SUBSTRATE FOR A LIQUID CELL AND A PRISM MITSUI CHEMICALS, INC. (JP) 2000-08-15 US disclosed
US-5990261-A Organic optical component MITSUI CHEMICALS, INC. (JP) 1999-11-23 US disclosed
EP-0826717-A1 An organic optical component MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1998-03-04 EP disclosed