Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | GRM8 | O00222 | 1/20 | 0.35 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.34 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8152915 | 0.91 | CRHR1 (0.34) | CRHR1TSHRGRM8GRM7GRM4 | |
| SCHEMBL8139794 | 0.87 | CRHR1 (0.40) | CRHR1GRM8GRM7GRM4P2RX7 | |
| SCHEMBL8140502 | 0.84 | SUV39H2 (0.34) | TSHRGRM8GRM7GRM4SUV39H2 | |
| SCHEMBL8149046 | 0.82 | TSHR (0.39) | CRHR1TSHRHTTLMNA | |
| SCHEMBL7135375 | 0.81 | CRHR1 (0.34) | CRHR1 | |
| SCHEMBL8148200 | 0.81 | TSHR (0.38) | CRHR1TSHRSUV39H2HTTMAPK1 | |
| SCHEMBL8151719 | 0.81 | CRHR1 (0.38) | CRHR1GRM8GRM7GRM4P2RX7 | |
| SCHEMBL8152497 | 0.79 | CRHR1 (0.35) | CRHR1GRM8GRM7GRM4P2RX7 | |
| SCHEMBL8146626 | 0.75 | CRHR1 (0.36) | CRHR1TSHRSUV39H2HTTLMNA | |
| SCHEMBL8140486 | 0.75 | CRHR1 (0.36) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994877-A1 | IMIDAZOPYRIMIDINES AND IMIDAZOPYRIDINES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | Du Pont Pharmaceuticals Company (US) | 2000-04-26 | — | — | EP | disclosed |
| WO-1999001454-A1 | IMIDAZOPYRIMIDINES AND IMIDAZOPYRIDINES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | DU PONT PHARMACEUTICALS COMPANY (US) | 1999-01-14 | — | — | WO | disclosed |