Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | F2 | P00734 | 1/20 | 0.49 |
| ▸ | PREP | P48147 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8153242 | 1.00 | MEN1 (0.55) | MEN1NPC1RAB9AKMT2AF2 | |
| SCHEMBL10507275 | 0.90 | NPC1 (0.62) | MEN1NPC1RAB9AKMT2APREP | |
| SCHEMBL10507283 | 0.90 | NPC1 (0.62) | MEN1NPC1RAB9AKMT2APREP | |
| SCHEMBL7372462 | 0.88 | MEN1 (0.50) | MEN1NPC1RAB9AKMT2AF2 | |
| SCHEMBL9774377 | 0.87 | PREP (0.66) | MEN1NPC1RAB9AKMT2APREP | |
| SCHEMBL10509401 | 0.87 | MEN1 (0.57) | MEN1NPC1RAB9AKMT2APREP | |
| SCHEMBL10509400 | 0.87 | MEN1 (0.57) | MEN1NPC1RAB9AKMT2APREP | |
| SCHEMBL10506399 | 0.85 | MEN1 (0.56) | MEN1NPC1RAB9AKMT2APREP | |
| SCHEMBL6285952 | 0.84 | PREP (0.65) | MEN1NPC1RAB9AKMT2APREP | |
| SCHEMBL6285958 | 0.84 | PREP (0.65) | MEN1NPC1RAB9AKMT2APREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6017929-A | Cholinesterase activator | ZERIA PHARMACEUTICAL CO., LTD. (JP) | 2000-01-25 | — | — | US | disclosed |
| EP-0754454-A1 | CHOLINESTERASE ACTIVATOR | ZERIA PHARMACEUTICAL CO., LTD. (JP) | 1997-01-22 | — | — | EP | disclosed |
| US-4912128-A | Inhibiting endopeptidase | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-03-27 | — | — | US | disclosed |
| EP-0286927-A2 | Pyrrolidine-2-(1,3-dicarbonyl) derivatives, process for their preparation, agents containing them as well as their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-10-19 | — | — | EP | disclosed |