Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | PDE9A | O76083 | 1/20 | 0.30 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12777383 | 1.00 | HCAR2 (0.40) | HCAR2JAK2THRBPDE9AEIF4A3 | |
| SCHEMBL8153470 | 0.79 | HCAR2 (0.49) | HCAR2JAK2THRBEIF4A3 | |
| SCHEMBL12777395 | 0.77 | PTK2 (0.35) | HCAR2JAK2THRB | |
| SCHEMBL8159263 | 0.77 | PTK2 (0.35) | HCAR2JAK2THRB | |
| SCHEMBL12777412 | 0.77 | JAK2 (0.39) | HCAR2JAK2THRB | |
| SCHEMBL12777394 | 0.67 | HCAR2 (0.39) | HCAR2JAK2THRBEIF4A3 | |
| SCHEMBL8153482 | 0.67 | HCAR2 (0.39) | HCAR2JAK2THRBEIF4A3 | |
| SCHEMBL8157829 | 0.67 | SMN1; SMN2 (0.36) | HCAR2 | |
| SCHEMBL12777370 | 0.67 | SMN1; SMN2 (0.36) | HCAR2 | |
| SCHEMBL12777390 | 0.62 | HCAR2 (0.49) | HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7902252-B2 | Inhibitors of D-amino acid oxidase | SEPRACOR, INC. (US) | 2011-03-08 | — | — | US | disclosed |
| WO-2011011330-A2 | INHIBITORS OF D-AMINO ACID OXIDASE | SEPRACOR INC. (US) | 2011-01-27 | — | — | WO | disclosed |
| US-20100029737-A1 | INHIBITORS OF D-AMINO ACID OXIDASE | SEPRACOR INC. (US) | 2010-02-04 | — | — | US | disclosed |
| US-20090099248-A1 | INHIBITORS OF D-AMINO ACID OXIDASE | SEPRACOR INC. (US) | 2009-04-16 | — | — | US | disclosed |
| WO-2008089453-A2 | INHIBITORS OF D-AMINO ACID OXIDASE | SEPRACOR INC. (US) | 2008-07-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099248-A1 | INHIBITORS OF D-AMINO ACID OXIDASE | DDO, DAO, ACHE | HCAR2 2765/4885JAK2 3162/4885THRB 3901/4885 |
| US-20100029737-A1 | INHIBITORS OF D-AMINO ACID OXIDASE | DDO, DAO, ACHE | HCAR2 2765/4885JAK2 3162/4885THRB 3901/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.