Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.48 |
| ▸ | KDM1A | O60341 | 2/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.39 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | AR | P10275 | 2/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8153779 | 1.00 | TRPV4 (0.48) | TRPV4KDM1ACYP11B1CYP11B2PARP10 | |
| SCHEMBL8153776 | 1.00 | TRPV4 (0.48) | TRPV4KDM1ACYP11B1CYP11B2PARP10 | |
| SCHEMBL8161250 | 1.00 | TRPV4 (0.48) | TRPV4KDM1ACYP11B1CYP11B2PARP10 | |
| SCHEMBL8161251 | 1.00 | TRPV4 (0.48) | TRPV4KDM1ACYP11B1CYP11B2PARP10 | |
| SCHEMBL8153483 | 1.00 | TRPV4 (0.48) | TRPV4KDM1ACYP11B1CYP11B2PARP10 | |
| SCHEMBL8155469 | 0.99 | TRPV4 (0.49) | TRPV4KDM1ACYP11B1CYP11B2PARP10 | |
| SCHEMBL8155466 | 0.99 | TRPV4 (0.49) | TRPV4KDM1ACYP11B1CYP11B2PARP10 | |
| SCHEMBL8147235 | 0.95 | TRPV4 (0.50) | TRPV4KDM1ACYP11B1CYP11B2PARP10 | |
| SCHEMBL8147234 | 0.95 | TRPV4 (0.50) | TRPV4KDM1ACYP11B1CYP11B2PARP10 | |
| SCHEMBL9590952 | 0.93 | TRPV4 (0.41) | TRPV4KDM1ACYP11B1CYP11B2AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE36849-E | 2-(4-(ALK(EN)YL, ALKOXY, ALKANOYL)-4'-BICYCLOHEXYL)-1-(2,3-(HALO OR NITRILE),4-HALOPHENYL)ETHANE COMPOUNDS; ELECTROOPTICAL DISPLAY WITH MULTIPLEX OPERATION COMPRISING A LIQUID CRYSTAL MIXTURE AS DIELECTRIC | MERCK PATENT GMBH (DE) | 2000-09-05 | — | — | US | disclosed |
| US-4710315-A | USE WITH MULTIPLEXIBLE DISPLAYS HAVING HIGH DENSITY IMAGES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1987-12-01 | — | — | US | disclosed |