Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 13/20 | 0.45 |
| ▸ | PDE5A | O76074 | 4/20 | 0.37 |
| ▸ | PDE4A | P27815 | 4/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.37 |
| ▸ | ICMT | O60725 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PI4KA | P42356 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8155128 | 0.85 | GRM2 (0.39) | GRM2PDE4BPIK3CA | |
| SCHEMBL1827372 | 0.78 | GRM2 (0.61) | GRM2 | |
| SCHEMBL4682912 | 0.77 | GRM2 (0.36) | GRM2PIK3CDPIK3CAPI4KAPIK3CG | |
| SCHEMBL4683778 | 0.77 | GRM2 (0.36) | GRM2PIK3CDPIK3CAPI4KAPIK3CG | |
| SCHEMBL4682908 | 0.77 | GRM2 (0.36) | GRM2PIK3CDPIK3CAPI4KAPIK3CG | |
| SCHEMBL8160841 | 0.76 | GRM2 (0.40) | GRM2PIK3CDPIK3CAPI4KAPIK3CG | |
| SCHEMBL8166792 | 0.76 | GRM2 (0.45) | GRM2PIK3CDPIK3CAPI4KAPIK3CG | |
| SCHEMBL8160720 | 0.74 | TNF (0.41) | GRM2PDE5APDE4APDE4BPDE4C | |
| SCHEMBL4682658 | 0.73 | PDE1C (0.43) | GRM2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL15803817 | 0.69 | GRM2 (0.42) | GRM2PIK3CDPIK3CAPI4KAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134708-B1 | 3-CYANO-4-(4-TETRAHYDROPYRAN-PHENYL)-PYRIDIN-2-ONE DERIVATIVES | ORTHO MCNEIL JANSSEN PHARM (US) | 2011-05-11 | — | — | EP | disclosed |
| WO-2008107481-A1 | 3-CYANO-4-(4-TETRAHYDROPYRAN-PHENYL)-PYRIDIN-2-ONE DERIVATIVES | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC (US) | 2008-09-12 | — | — | WO | disclosed |
| WO-2008107480-A1 | 1,4-DISUBSTITUTED 3-CYANO-PYRIDONE DERIVATIVES AND THEIR USE AS POSITIVE MGLUR2 -RECEPTOR MODULATORS | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC (US) | 2008-09-12 | — | — | WO | disclosed |
| WO-2008107479-A1 | 3-CYANO-4-(4-PHENYL-PIPERIDIN-1-YL)-PYRIDIN-2-ONE DERIVATIVES | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC (US) | 2008-09-12 | — | — | WO | disclosed |