Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 4/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 4/20 | 0.38 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HTR4 | Q13639 | 3/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8154473 | 0.85 | GRM2 (0.45) | GRM2PDE4BPIK3CA | |
| SCHEMBL1828011 | 0.80 | LMNA (0.57) | GRM2CECR2LMNAMAPTCYP2C9 | |
| SCHEMBL8160720 | 0.78 | TNF (0.41) | GRM2BRD9NPSR1PDE4BLMNA | |
| SCHEMBL8154793 | 0.78 | GRM2 (0.42) | GRM2LCKKITSRCKDR | |
| SCHEMBL8146318 | 0.78 | GRM2 (0.41) | GRM2LCKKITSRCKDR | |
| SCHEMBL1827372 | 0.65 | GRM2 (0.61) | GRM2LMNAMAPTCYP2C9 | |
| SCHEMBL24363726 | 0.64 | CECR2 (0.46) | GRM2LCKKITSRCKDR | |
| SCHEMBL4682912 | 0.64 | GRM2 (0.36) | GRM2LCKKITSRCKDR | |
| SCHEMBL4683778 | 0.64 | GRM2 (0.36) | GRM2LCKKITSRCKDR | |
| SCHEMBL4682908 | 0.64 | GRM2 (0.36) | GRM2LCKKITSRCKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134708-B1 | 3-CYANO-4-(4-TETRAHYDROPYRAN-PHENYL)-PYRIDIN-2-ONE DERIVATIVES | ORTHO MCNEIL JANSSEN PHARM (US) | 2011-05-11 | — | — | EP | disclosed |
| WO-2008107481-A1 | 3-CYANO-4-(4-TETRAHYDROPYRAN-PHENYL)-PYRIDIN-2-ONE DERIVATIVES | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC (US) | 2008-09-12 | — | — | WO | disclosed |