Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 16/20 | 0.59 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1829307 | 0.86 | GRM2 (0.78) | GRM2 | |
| SCHEMBL10324147 | 0.68 | GRM2 (1.00) | GRM2 | |
| SCHEMBL741461 | 0.67 | GRM2 (1.00) | GRM2 | |
| SCHEMBL12657862 | 0.65 | PDE3B (0.48) | GRM2 | |
| SCHEMBL8164661 | 0.65 | GRM2 (0.43) | GRM2 | |
| SCHEMBL8155128 | 0.65 | GRM2 (0.39) | GRM2 | |
| SCHEMBL10324063 | 0.65 | GRM2 (0.80) | GRM2 | |
| SCHEMBL739257 | 0.64 | GRM2 (0.54) | GRM2 | |
| SCHEMBL15672416 | 0.64 | GRM2 (0.49) | GRM2SYK | |
| SCHEMBL8146318 | 0.63 | GRM2 (0.41) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008107481-A1 | 3-CYANO-4-(4-TETRAHYDROPYRAN-PHENYL)-PYRIDIN-2-ONE DERIVATIVES | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC (US) | 2008-09-12 | — | — | WO | disclosed |