Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | AGER | Q15109 | 1/20 | 0.36 |
| ▸ | GPR3 | P46089 | 2/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25998819 | 0.85 | ALDH1A1 (0.45) | CRHR1ALDH1A1GAAPOLBTHRB | |
| SCHEMBL27051423 | 0.80 | GAA (0.60) | MEN1KMT2AALDH1A1GAATSHR | |
| SCHEMBL8148399 | 0.80 | S1PR1 (0.46) | MEN1KMT2ACRHR1ALDH1A1HPGD | |
| SCHEMBL7651507 | 0.80 | KDM4E (0.46) | MEN1KMT2AHTTALDH1A1GAA | |
| SCHEMBL8163202 | 0.78 | FFAR1 (0.39) | ALDH1A1HPGDGAAPOLBTHRB | |
| SCHEMBL19616709 | 0.77 | MAPT (0.43) | CRHR1ALDH1A1HPGDGAAPOLB | |
| SCHEMBL29493403 | 0.77 | MAPT (0.43) | CRHR1ALDH1A1HPGDGAAPOLB | |
| SCHEMBL8156359 | 0.77 | MCHR1 (0.47) | ALDH1A1GAAPOLBTHRB | |
| SCHEMBL15880460 | 0.77 | CA12 (0.49) | MEN1KMT2AALDH1A1GAAPOLB | |
| SCHEMBL27493434 | 0.77 | ALDH1A1 (0.48) | MEN1KMT2AHTTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6071927-A | Spiro-piperidine derivatives and their use as therapeutic agents | MERCK SHARP & DOHME LTD. (GB) | 2000-06-06 | — | — | US | disclosed |
| CN-1223656-A | Spiro-piperidine derivatives and their use as therapeutic agents | MERCK SHARP & DOHME (GB) | 1999-07-21 | — | — | CN | disclosed |
| EP-0906315-A1 | SPIRO-PIPERIDINE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LTD. (GB) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997049710-A1 | SPIRO-PIPERIDINE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LIMITED (GB) | 1997-12-31 | — | — | WO | disclosed |