Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 3/20 | 0.38 |
| ▸ | RORC | P51449 | 5/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8157917 | 1.00 | MEN1 (0.40) | MEN1KMT2AMAPK1HTTTACR1 | |
| SCHEMBL6209857 | 0.90 | NR1H2 (0.41) | MEN1KMT2ARORC | |
| SCHEMBL5783560 | 0.90 | NR1H2 (0.41) | MEN1KMT2ARORC | |
| SCHEMBL5783564 | 0.90 | NR1H2 (0.41) | MEN1KMT2ARORC | |
| SCHEMBL8155842 | 0.78 | TACR1 (0.40) | MEN1KMT2AMAPK1HTTTACR1 | |
| SCHEMBL8459509 | 0.73 | CHRM2 (0.37) | MEN1KMT2AOPRK1SIGMAR1 | |
| SCHEMBL17747356 | 0.71 | RIPK1 (0.51) | MEN1KMT2A | |
| SCHEMBL18406185 | 0.71 | RIPK1 (0.51) | MEN1KMT2A | |
| SCHEMBL8156067 | 0.71 | NR1H2 (0.37) | MEN1KMT2AHTT | |
| SCHEMBL8156075 | 0.71 | NR1H2 (0.37) | MEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6071927-A | Spiro-piperidine derivatives and their use as therapeutic agents | MERCK SHARP & DOHME LTD. (GB) | 2000-06-06 | — | — | US | disclosed |