SCHEMBL8158322

SCHEMBL8158322

O=S(OCCc1ccccc1)OCCc1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 1/20 0.48
CA2 P00918 1/20 0.48
CA9 Q16790 1/20 0.48
TDP1 Q9NUW8 4/20 0.45
EPHX2 P34913 1/20 0.44
IDO1 P14902 1/20 0.43
HCAR2 Q8TDS4 1/20 0.43
NPC1 O15118 2/20 0.42
RAB9A P51151 2/20 0.42
ALDH1A1 P00352 2/20 0.42
HPGD P15428 2/20 0.42
HSD17B10 Q99714 2/20 0.42
ALOX15 P16050 1/20 0.42
ALOX12 P18054 1/20 0.42
CASP1 P29466 1/20 0.42
FFAR1 O14842 1/20 0.42
ESR1 P03372 1/20 0.42
ESR2 Q92731 1/20 0.42
KEAP1 Q14145 1/20 0.41
LMNA P02545 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL777922 0.87 IDO1 (0.55) TDP1IDO1NPC1RAB9AFFAR1
SCHEMBL775867 0.85 IDO1 (0.48) IDO1FFAR1LMNASMN1; SMN2MAPK1
SCHEMBL27466857 0.83 TDP1 (0.47) CA1CA2CA9TDP1EPHX2
SCHEMBL31499294 0.78 TAAR1 (0.45) IDO1FFAR1HTR2ATAAR1GLA
SCHEMBL776935 0.76 TSHR (0.52) CA1CA2CA9TDP1EPHX2
SCHEMBL17024044 0.74 RECQL (0.44) CA1CA2CA9TDP1NPC1
SCHEMBL7698932 0.74 TSHR (0.41) TDP1EPHX2IDO1ALDH1A1LMNA
SCHEMBL3819917 0.73 CA1 (0.48) CA1CA2CA9TDP1IDO1
SCHEMBL198134 0.72 TSHR (0.52) CA1CA2CA9TDP1IDO1
SCHEMBL6341147 0.72 ALDH1A1 (0.52) CA1CA2CA9TDP1IDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1003469-A2 FRAGRANCE PRECURSORS GIVAUDAN-ROURE (INTERNATIONAL) S.A. (CH) 2000-05-31 EP disclosed
WO-1997030687-A2 FRAGRANCE PRECURSORS GIVAUDAN-ROURE (INTERNATIONAL) S.A. (CH) 1997-08-28 WO disclosed
US-4190602-A PHOTOCHEMICAL SENSITIZERS BY REACTION OF SULFUROUS ACID ESTER OR THIONYL CHLORIDE AND A PRIMARY ALCOHOL CIBA-GEIGY CORPORATION (US) 1980-02-26 US disclosed