Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 5/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.54 |
| ▸ | HTR2A | P28223 | 7/20 | 0.50 |
| ▸ | HRH1 | P35367 | 7/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.43 |
| ▸ | METAP1 | P53582 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 5/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8152267 | 1.00 | SLC6A2 (0.54) | SLC6A2SLC6A4HTR2AHRH1ALDH1A1 | |
| SCHEMBL8152263 | 1.00 | SLC6A2 (0.54) | SLC6A2SLC6A4HTR2AHRH1ALDH1A1 | |
| SCHEMBL12362873 | 1.00 | SLC6A2 (0.54) | SLC6A2SLC6A4HTR2AHRH1ALDH1A1 | |
| SCHEMBL8152258 | 1.00 | SLC6A2 (0.54) | SLC6A2SLC6A4HTR2AHRH1ALDH1A1 | |
| SCHEMBL8151548 | 0.83 | HTR2A (0.47) | SLC6A2SLC6A4HTR2AHRH1SLC6A3 | |
| SCHEMBL6268863 | 0.83 | HTR2A (0.53) | SLC6A2SLC6A4HTR2AHRH1HTR2C | |
| SCHEMBL9334169 | 0.83 | HTR2A (0.53) | SLC6A2SLC6A4HTR2AHRH1HTR2C | |
| SCHEMBL8151546 | 0.83 | HTR2A (0.47) | SLC6A2SLC6A4HTR2AHRH1SLC6A3 | |
| SCHEMBL8159949 | 0.83 | HTR2A (0.53) | SLC6A2SLC6A4HTR2AHRH1HTR2C | |
| SCHEMBL8159528 | 0.83 | HTR2A (0.47) | SLC6A2SLC6A4HTR2AHRH1SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6136803-A | CYCLOALKYL ETHER INDANAMINE COMPOUNDS | MERRELL PHARMACEUTICALS INC. (US) | 2000-10-24 | — | — | US | disclosed |
| JP-2000119326-A | CATALYST COMPOSITION BASED ON IRON AND PRODUCTION OF SYNDIOTACTIC 1,2-POLYBUTADIENE | BRIDGESTONE CORP | 2000-04-25 | — | — | JP | disclosed |
| US-5561152-A | 1-PHENOXY-2-(AMINOMETHYL)INDAN DERIVATIVES; ADRENERGIC BLOCKING AGENT; INHIBITORS OF BOTH NOREPINEPHRINE AND SEROTONIN UPTAKE | MERRELL PHARMACEUTICALS INC. (US) | 1996-10-01 | — | — | US | disclosed |
| EP-0303961-B1 | Novel antidepressants | MERRELL DOW PHARMA (US) | 1994-04-13 | — | — | EP | disclosed |
| EP-0371508-B1 | PHENOXY AND PHENYLTHIO, AMINO SUBSTITUTED BENZOCYCLOALKANE DERIVATIVES IN THE TREATMENT AND PREVENTION OF DRUG-RESISTANT PROTOZOAL INFECTIONS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-07-14 | — | — | EP | disclosed |
| US-5149714-A | Antidepressants | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-09-22 | — | — | US | disclosed |
| US-5134168-A | PHENOXY AND PHENYLTHIO, AMINO SUBSTITUTED BENZOCYCLOALKANE DERIVATIVES IN THE TREATMENT AND PREVENTION OF DRUG-RESISTANT PROTOZOAL INFECTIONS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-07-28 | — | — | US | disclosed |
| EP-0371508-A1 | Phenoxy and phenylthio, amino substituted benzocycloalkane derivatives in the treatment and prevention of drug-resistant protozoal infections | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-06-06 | — | — | EP | disclosed |
| EP-0303961-A2 | Novel antidepressants | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-02-22 | — | — | EP | disclosed |