Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.53 |
| ▸ | HRH1 | P35367 | 4/20 | 0.53 |
| ▸ | CDK8 | P49336 | 1/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6268863 | 1.00 | HTR2A (0.53) | HTR2AHRH1CDK8CDK5SLC6A2 | |
| SCHEMBL9334169 | 1.00 | HTR2A (0.53) | HTR2AHRH1CDK8CDK5SLC6A2 | |
| SCHEMBL7306430 | 0.84 | SLC6A2 (0.38) | HTR2AHRH1CDK8CDK5SLC6A2 | |
| SCHEMBL8152258 | 0.83 | SLC6A2 (0.54) | HTR2AHRH1SLC6A2SLC6A4HTR2C | |
| SCHEMBL8152263 | 0.83 | SLC6A2 (0.54) | HTR2AHRH1SLC6A2SLC6A4HTR2C | |
| SCHEMBL8152267 | 0.83 | SLC6A2 (0.54) | HTR2AHRH1SLC6A2SLC6A4HTR2C | |
| SCHEMBL8158561 | 0.83 | SLC6A2 (0.54) | HTR2AHRH1SLC6A2SLC6A4HTR2C | |
| SCHEMBL12362873 | 0.83 | SLC6A2 (0.54) | HTR2AHRH1SLC6A2SLC6A4HTR2C | |
| SCHEMBL9422155 | 0.81 | OPRM1 (0.42) | BLMTSHRSIGMAR1OPRM1 | |
| SCHEMBL11551882 | 0.80 | HTR2A (0.51) | HTR2AHRH1CDK8CDK5SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000005206-A1 | ARYLPIPERAZINE DERIVATIVES USEFUL AS URO-SELECTIVE ALPHA-1-ADRENOCEPTOR BLOCKERS | RANBAXY LABORATORIES LIMITED (US) | 2000-02-03 | — | — | WO | claimed |
| EP-0303961-B1 | Novel antidepressants | MERRELL DOW PHARMA (US) | 1994-04-13 | — | — | EP | disclosed |