Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.62 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.53 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.42 |
| ▸ | NAAA | Q02083 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22699875 | 0.98 | EPHX1 (0.66) | EPHX1EPHX2TET2NAAARECQL | |
| SCHEMBL12820520 | 0.81 | EPHX1 (0.61) | EPHX1NAAAHTTSMN1; SMN2TSHR | |
| SCHEMBL7425848 | 0.81 | EPHX1 (0.57) | EPHX1EPHX2NAAASMN1; SMN2TSHR | |
| SCHEMBL2866869 | 0.79 | EPHX1 (0.65) | EPHX1NAAAHTTSMN1; SMN2TSHR | |
| SCHEMBL28858179 | 0.79 | EPHX1 (0.59) | EPHX1EPHX2NAAAHTTSMN1; SMN2 | |
| SCHEMBL965658 | 0.79 | EPHX1 (0.96) | EPHX1NAAAHTTSMN1; SMN2TSHR | |
| SCHEMBL31512356 | 0.78 | EPHX1 (0.62) | EPHX1NAAAHTTSMN1; SMN2TSHR | |
| SCHEMBL29372337 | 0.78 | EPHX1 (0.68) | EPHX1EPHX2NAAAHTTSMN1; SMN2 | |
| SCHEMBL12335551 | 0.77 | EPHX1 (0.50) | EPHX1NAAAHTTTSHRCYP2C19 | |
| SCHEMBL4436771 | 0.77 | EPHX2 (0.59) | EPHX1EPHX2NAAATSHRGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008101665-A1 | MACROCYCLIC COMPOUNDS AS HCV NS3 PROTEASE INHIBITORS | NOVARTIS AG (CH) | 2008-08-28 | — | — | WO | disclosed |