Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NAAA | Q02083 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PPID | Q08752 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12891793 | 0.81 | EPHX1 (0.51) | EPHX1GAAEPHX2ALDH1A1NAAA | |
| SCHEMBL8158699 | 0.81 | EPHX1 (0.62) | EPHX1GAAEPHX2ALDH1A1SMN1; SMN2 | |
| SCHEMBL22699875 | 0.79 | EPHX1 (0.66) | EPHX1EPHX2KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL12635064 | 0.78 | EPHX1 (0.55) | EPHX1GAAEPHX2ALDH1A1NAAA | |
| SCHEMBL12166449 | 0.78 | EPHX2 (0.44) | EPHX1GAAEPHX2KMT2AMGAM | |
| SCHEMBL15777906 | 0.78 | EPHX1 (0.89) | EPHX1GAAKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL3488684 | 0.76 | GAA (0.55) | GAAEPHX2KMT2AMGAMSI | |
| SCHEMBL2482646 | 0.76 | GAA (0.59) | GAAEPHX2MGAMSIMGAM2 | |
| SCHEMBL7417094 | 0.75 | GAA (0.44) | EPHX1GAAEPHX2KMT2AMGAM | |
| SCHEMBL27436864 | 0.75 | MGAM (0.58) | EPHX1GAAKMT2AMGAMSI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211228-B1 | COMPOUNDS WITH AMINO, GUANIDINO AND AMIDINO HETEROCYCLIC COMPOUNDS | AXYS PHARMACEUTICALS, INC | 2001-04-03 | — | — | US | disclosed |
| US-6022969-A | Compositions and methods for treating mast-cell mediated conditions | AXYS PHARMACEUTICALS, INC. (US) | 2000-02-08 | — | — | US | disclosed |
| EP-0782571-A1 | COMPOSITIONS AND METHODS FOR TREATING MAST-CELL INFLAMMATORY CONDITION | ARRIS PHARMACEUTICAL CORPORATION (US) | 1997-07-09 | — | — | EP | disclosed |
| WO-1996009297-A1 | COMPOSITIONS AND METHODS FOR TREATING MAST-CELL INFLAMMATORY CONDITION | ARRIS PHARMACEUTICAL CORPORATION (US) | 1996-03-28 | — | — | WO | disclosed |