Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 4/20 | 0.59 |
| ▸ | HTR1B | P28222 | 4/20 | 0.59 |
| ▸ | HTR1A | P08908 | 3/20 | 0.59 |
| ▸ | HTR7 | P34969 | 2/20 | 0.59 |
| ▸ | HTR5A | P47898 | 2/20 | 0.59 |
| ▸ | HTR2A | P28223 | 2/20 | 0.59 |
| ▸ | HTR2B | P41595 | 2/20 | 0.59 |
| ▸ | HTR2C | P28335 | 1/20 | 0.59 |
| ▸ | HTR1E | P28566 | 1/20 | 0.59 |
| ▸ | HTR1F | P30939 | 1/20 | 0.59 |
| ▸ | HTR3A | P46098 | 1/20 | 0.59 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL8624157 | 0.96 | HTR1D (0.56) | HTR1DHTR1BHTR1AHTR7HTR5A | |
| Succinic Acid SCHEMBL8383594 | 0.92 | HTR1A (0.52) | HTR1DHTR1BHTR1AHTR7HTR5A | |
| Naratriptan SCHEMBL8716118 | 0.77 | HTR1D (0.70) | HTR1DHTR1BHTR1AHTR7HTR5A | |
| SCHEMBL8158813 | 0.75 | HTR1D (0.45) | HTR1DHTR1BHTR1AHTR7HTR5A | |
| Sumatriptan SCHEMBL1482 | 0.74 | HTR1A (1.00) | HTR1DHTR1BHTR1AHTR7HTR5A | |
| Sumatriptan SCHEMBL183393 | 0.74 | HTR1A (1.00) | HTR1DHTR1BHTR1AHTR7HTR5A | |
| Sumatriptan SCHEMBL29450235 | 0.74 | HTR1A (1.00) | HTR1DHTR1BHTR1AHTR7HTR5A | |
| SCHEMBL8990519 | 0.74 | HTR1D (0.43) | HTR1DHTR1BHTR1AHTR7HTR5A | |
| Sumatriptan SCHEMBL4916383 | 0.73 | HTR1A (0.98) | HTR1DHTR1BHTR1AHTR7HTR5A | |
| Sumatriptan SCHEMBL1421675 | 0.73 | HTR1A (0.98) | HTR1DHTR1BHTR1AHTR7HTR5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5807571-A | Transdermal therapeutic systems for administering indole serotonin agonists | LTS LOHMANN THERAPIE-SYSTEME GMBH (DE) | 1998-09-15 | — | — | US | claimed |
| US-5705520-A | FOR TREATMENT OF MIGRAINES | GLAXO GROUP LIMITED (GB) | 1998-01-06 | — | — | US | claimed |
| US-5705506-A | TREATMENT OF MIGRAINES OR HEADACHES | LABORATOIRES GLAXO SA (FR) | 1998-01-06 | — | — | US | claimed |
| US-5693654-A | Medicaments for treating intraocular pressure | GLAXO GROUP LIMITED (GB) | 1997-12-02 | — | — | US | claimed |
| EP-0975594-A1 | PROCESS FOR THE PRODUCTION OF INDOLE DERIVATIVES | Pfizer Limited (GB) | 2000-02-02 | — | — | EP | disclosed |
| US-5863559-A | 3-(2-(DIMETHYLAMINO)ETHYL)-N-METHYL-1H-INDOLE-5-METHANESULPHON AMIDE OR A PHARMACEUTICALLY ACCEPTABLE SALT OR SOLVATE THEREOF IN TABLET FORM | GLAXO GROUP LIMITED (GB) | 1999-01-26 | — | — | US | disclosed |
| US-5863559-A | 3-(2-(DIMETHYLAMINO)ETHYL)-N-METHYL-1H-INDOLE-5-METHANESULPHON AMIDE OR A PHARMACEUTICALLY ACCEPTABLE SALT OR SOLVATE THEREOF IN TABLET FORM | GLAXO GROUP LIMITED (GB) | 1999-01-26 | — | — | US | disclosed |
| WO-1999002493-A1 | PROCESS FOR THE PRODUCTION OF INDOLE DERIVATIVES | PFIZER LIMITED (GB) | 1999-01-21 | — | — | WO | disclosed |
| US-5807571-A | Transdermal therapeutic systems for administering indole serotonin agonists | LTS LOHMANN THERAPIE-SYSTEME GMBH (DE) | 1998-09-15 | — | — | US | disclosed |
| US-5744482-A | Serotonin agonist in combination with a tachykinin receptor antagonist in the treatment or prevention of migraine | ELI LILLY AND COMPANY (US) | 1998-04-28 | — | — | US | disclosed |
| US-5705520-A | FOR TREATMENT OF MIGRAINES | GLAXO GROUP LIMITED (GB) | 1998-01-06 | — | — | US | disclosed |
| US-5705506-A | TREATMENT OF MIGRAINES OR HEADACHES | LABORATOIRES GLAXO SA (FR) | 1998-01-06 | — | — | US | disclosed |
| US-5693654-A | Medicaments for treating intraocular pressure | GLAXO GROUP LIMITED (GB) | 1997-12-02 | — | — | US | disclosed |
| US-5693654-A | Medicaments for treating intraocular pressure | GLAXO GROUP LIMITED (GB) | 1997-12-02 | — | — | US | disclosed |