SCHEMBL8159162

SCHEMBL8159162

CC(C)(C)c1cc(COCC(=O)O)cc(C(C)(C)C)c1O

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR55 Q9Y2T6 1/20 0.52
VCAM1 P19320 2/20 0.52
ALDH1A1 P00352 5/20 0.46
KMT2A Q03164 4/20 0.46
TSHR P16473 3/20 0.46
MEN1 O00255 3/20 0.46
MAPK1 P28482 3/20 0.46
CYP1A2 P05177 2/20 0.46
CYP3A4 P08684 2/20 0.46
BLM P54132 2/20 0.46
ATM Q13315 2/20 0.46
HIF1A Q16665 2/20 0.46
NPSR1 Q6W5P4 2/20 0.46
MAPT P10636 2/20 0.46
USP2 O75604 1/20 0.46
CYP2D6 P10635 1/20 0.46
GAA P10253 5/20 0.46
LMNA P02545 3/20 0.46
TDP1 Q9NUW8 1/20 0.45
GMNN O75496 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL39028 0.84 ALDH1A1 (0.57) ALDH1A1KMT2ATSHRMEN1MAPK1
SCHEMBL11650738 0.80 ALDH1A1 (0.53) ALDH1A1KMT2ATSHRMEN1MAPK1
SCHEMBL38555 0.80 ALDH1A1 (0.53) GPR55ALDH1A1KMT2ATSHRMEN1
SCHEMBL10559529 0.79 CD69 (0.49) NPSR1CYP2C19HMGCRKDM4ESMN1; SMN2
SCHEMBL6403668 0.79 GAA (0.53) GPR55ALDH1A1KMT2ATSHRMEN1
Ammonia Solution, Strong SCHEMBL3948778 0.79 ALDH1A1 (0.52) GPR55ALDH1A1KMT2ATSHRMEN1
SCHEMBL9486485 0.79 ALDH1A1 (0.55) ALDH1A1KMT2ATSHRMEN1MAPK1
SCHEMBL2680047 0.79 ALDH1A1 (0.52) ALDH1A1KMT2ATSHRMEN1MAPK1
SCHEMBL3125775 0.78 GAA (0.47) GPR55VCAM1ALDH1A1KMT2ATSHR
Ethylene SCHEMBL3949822 0.77 ALDH1A1 (0.50) GPR55ALDH1A1KMT2ATSHRMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0737659-B1 7-Substituted quinone methides as inhibitors for unsaturated monomers CIBA SC HOLDING AG (CH) 2000-07-05 EP disclosed
US-5750765-A 7-substituted quinone methides as inhibitors for unsaturated monomers CIBA SPECIALTY CHEMICALS CORPORATION (US) 1998-05-12 US disclosed
US-5670692-A 7-substituted quinone methides as inhibitors for unsaturated monomers CIBA-GEIGY CORPORATION (US) 1997-09-23 US disclosed
US-5583247-A PREMATURE POLYMERIZATION STABILIZERS CIBA-GEIGY CORPORATION (US) 1996-12-10 US disclosed
EP-0737659-A1 7-Substituted quinone methides as inhibitors for unsaturated monomers CIBA-GEIGY AG (CH) 1996-10-16 EP disclosed