Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | NAAA | Q02083 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | FPR2 | P25090 | 7/20 | 0.39 |
| ▸ | PROKR1 | Q8TCW9 | 7/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6390286 | 0.88 | KMT2A (0.45) | KMT2ANPC1TLR9ALDH1A1NAAA | |
| SCHEMBL5243713 | 0.85 | ALDH1A1 (0.43) | KMT2ANPC1TLR9ALDH1A1NAAA | |
| SCHEMBL5243164 | 0.83 | ALDH1A1 (0.60) | KMT2AALDH1A1MEN1POLBCYP2C19 | |
| SCHEMBL5244612 | 0.80 | NPC1 (0.53) | KMT2ANPC1TLR9FPR2PROKR1 | |
| SCHEMBL5285381 | 0.72 | KMT2A (0.58) | KMT2ANPC1TLR9ALDH1A1MEN1 | |
| SCHEMBL5288051 | 0.71 | KMT2A (0.57) | KMT2ANPC1TLR9ALDH1A1MEN1 | |
| SCHEMBL5281618 | 0.71 | KMT2A (0.49) | KMT2ANPC1TLR9ALDH1A1MEN1 | |
| SCHEMBL5244644 | 0.71 | KMT2A (0.62) | KMT2ANPC1TLR9ALDH1A1MEN1 | |
| SCHEMBL5244144 | 0.69 | ALDH1A1 (0.40) | KMT2AALDH1A1MEN1POLBMAPT | |
| SCHEMBL5290061 | 0.69 | SCD (0.47) | FPR2PROKR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008115259-A2 | DERIVATIVES OF BENZOXADIAZOLE SUITABLE FOR THE TREATMENT OF CELL PROLIFERATIVE DISEASES | RIGEL PHARMACEUTICALS, INC. (US) | 2008-09-25 | — | — | WO | disclosed |
| WO-2006002284-A1 | UBIQUITIN LIGASE INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2006-01-05 | — | — | WO | disclosed |