SCHEMBL8159367

SCHEMBL8159367

CCOC(=O)/C(=C\NC1CC1)C(=O)c1ccc(F)c(Cl)c1F

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 3/20 0.39
MAPT P10636 3/20 0.38
GAA P10253 3/20 0.38
MEN1 O00255 4/20 0.37
KMT2A Q03164 4/20 0.37
LMNA P02545 1/20 0.37
CYP1A2 P05177 1/20 0.37
CYP2C9 P11712 1/20 0.37
CYP2C19 P33261 1/20 0.37
DHODH Q02127 2/20 0.36
P2RX7 Q99572 4/20 0.35
TDP1 Q9NUW8 1/20 0.35
KDM4E B2RXH2 2/20 0.35
ALDH1A1 P00352 1/20 0.35
HPGD P15428 1/20 0.35
NPY1R P25929 1/20 0.35
NPY2R P49146 1/20 0.35
POLB P06746 2/20 0.34
GPR35 Q9HC97 1/20 0.34
CYP3A4 P08684 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4464758 1.00 NPSR1 (0.39) NPSR1MAPTGAAMEN1KMT2A
SCHEMBL9145727 0.89 MAPT (0.39) NPSR1MAPTGAAMEN1KMT2A
SCHEMBL9145729 0.89 MAPT (0.39) NPSR1MAPTGAAMEN1KMT2A
SCHEMBL9149464 0.87 NPSR1 (0.38) NPSR1MAPTGAAMEN1KMT2A
SCHEMBL9149478 0.87 NPSR1 (0.38) NPSR1MAPTGAAMEN1KMT2A
SCHEMBL9152339 0.87 NPSR1 (0.38) NPSR1MAPTGAAMEN1KMT2A
SCHEMBL9149471 0.87 NPSR1 (0.38) NPSR1MAPTGAAMEN1KMT2A
SCHEMBL8437121 0.87 POLB (0.39) NPSR1MAPTGAAMEN1KMT2A
SCHEMBL8437126 0.87 POLB (0.39) NPSR1MAPTGAAMEN1KMT2A
SCHEMBL9562451 0.87 POLB (0.39) NPSR1MAPTGAAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6114590-A Process for the preparation of polyhalogenated benzotrifluorides, benzotrichlorides and benzoyl chlorides and new trihalogenobenzotrichlorides and -benzoyl chlorides BAYER AKTIENGESELLSCHAFT (DE) 2000-09-05 US disclosed
US-6075165-A Process for the preparation of polyhalogenated benzotrifluorides, benzotrichlorides and benzoyl chlorides and new trihalogenobenzotrichlorides and -benzoyl chlorides BAYER AKTIENGESELLSCHAFT (DE) 2000-06-13 US disclosed
US-5599980-A Process for the preparation of polyhalogenated benzotrifluorides, benzotrichlorides and benzoyl chlorides and new trihalogenobenzotrichlorides and -benzoyl chlorides BAYER AKTIENGESELLSCHAFT (DE) 1997-02-04 US disclosed
US-5457104-A Antibacterials BAYER AKTIENGESELLSCHAFT (DE) 1995-10-10 US disclosed