Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sulfamerazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.92 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.92 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.68 |
| ▸ | FASN | P49327 | 1/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | AURKA | O14965 | 1/20 | 0.61 |
| ▸ | DHFR | P00374 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfamerazine SCHEMBL28028780 | 0.96 | MAPT (0.94) | MAPTCYP2C9NPSR1FASNMAPK1 | |
| Sulfamerazine SCHEMBL33999 | 0.96 | MAPT (1.00) | MAPTCYP2C9NPSR1FASNMAPK1 | |
| Sulfamerazine SCHEMBL29538415 | 0.96 | MAPT (1.00) | MAPTCYP2C9NPSR1FASNMAPK1 | |
| Sulfamerazine SCHEMBL5871007 | 0.94 | MAPT (0.97) | MAPTCYP2C9NPSR1FASNMAPK1 | |
| Sulfamerazine SCHEMBL93591 | 0.94 | MAPT (0.97) | MAPTCYP2C9NPSR1FASNMAPK1 | |
| Sulfamerazine SCHEMBL28859835 | 0.90 | MAPT (0.89) | MAPTCYP2C9NPSR1FASNMAPK1 | |
| Sulfamethazine SCHEMBL4231556 | 0.90 | MAPT (0.89) | MAPTCYP2C9NPSR1FASNMAPK1 | |
| Sulfamerazine SCHEMBL28086386 | 0.90 | MAPT (0.89) | MAPTCYP2C9NPSR1FASNMAPK1 | |
| Sulfamerazine SCHEMBL10619389 | 0.89 | MAPT (0.81) | MAPTCYP2C9NPSR1FASNMAPK1 | |
| Sulfamethazine SCHEMBL30306297 | 0.87 | MAPT (0.82) | MAPTCYP2C9NPSR1FASNMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6099864-A | In situ activation of microcapsules | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF THE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION (US) | 2000-08-08 | — | — | US | claimed |
| WO-1999059554-A1 | IN SITU ACTIVATION OF MICROCAPSULES | NASA/JOHNSON SPACE CENTER (US) | 1999-11-25 | — | — | WO | claimed |
| US-6099864-A | In situ activation of microcapsules | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF THE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION (US) | 2000-08-08 | — | — | US | disclosed |
| WO-1999059554-A1 | IN SITU ACTIVATION OF MICROCAPSULES | NASA/JOHNSON SPACE CENTER (US) | 1999-11-25 | — | — | WO | disclosed |