Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 12/20 | 0.44 |
| ▸ | HTR2C | P28335 | 12/20 | 0.44 |
| ▸ | HTR2B | P41595 | 12/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10516445 | 1.00 | HTR2A (0.44) | HTR2AHTR2CHTR2BHRH3SIGMAR1 | |
| SCHEMBL8066004 | 1.00 | HTR2A (0.44) | HTR2AHTR2CHTR2BHRH3SIGMAR1 | |
| SCHEMBL5675555 | 0.85 | HTR2A (0.38) | HTR2AHTR2CHTR2BHRH3SIGMAR1 | |
| SCHEMBL1443833 | 0.85 | HTR2A (0.38) | HTR2AHTR2CHTR2BHRH3SIGMAR1 | |
| SCHEMBL2903990 | 0.85 | HTR2A (0.38) | HTR2AHTR2CHTR2BHRH3SIGMAR1 | |
| SCHEMBL5676899 | 0.85 | HTR2A (0.38) | HTR2AHTR2CHTR2BHRH3SIGMAR1 | |
| SCHEMBL5677090 | 0.81 | HTR2A (0.36) | HTR2AHTR2CHTR2BHRH3SIGMAR1 | |
| SCHEMBL5679264 | 0.81 | HTR2A (0.36) | HTR2AHTR2CHTR2BHRH3SIGMAR1 | |
| SCHEMBL5679296 | 0.81 | HTR2A (0.36) | HTR2AHTR2CHTR2BHRH3SIGMAR1 | |
| SCHEMBL14076218 | 0.78 | DRD2 (0.50) | HTR2AHTR2CHTR2BHRH3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6136803-A | CYCLOALKYL ETHER INDANAMINE COMPOUNDS | MERRELL PHARMACEUTICALS INC. (US) | 2000-10-24 | — | — | US | disclosed |
| EP-0303961-B1 | Novel antidepressants | MERRELL DOW PHARMA (US) | 1994-04-13 | — | — | EP | disclosed |
| EP-0371508-B1 | PHENOXY AND PHENYLTHIO, AMINO SUBSTITUTED BENZOCYCLOALKANE DERIVATIVES IN THE TREATMENT AND PREVENTION OF DRUG-RESISTANT PROTOZOAL INFECTIONS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-07-14 | — | — | EP | disclosed |
| US-5134168-A | PHENOXY AND PHENYLTHIO, AMINO SUBSTITUTED BENZOCYCLOALKANE DERIVATIVES IN THE TREATMENT AND PREVENTION OF DRUG-RESISTANT PROTOZOAL INFECTIONS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-07-28 | — | — | US | disclosed |
| EP-0371508-A1 | Phenoxy and phenylthio, amino substituted benzocycloalkane derivatives in the treatment and prevention of drug-resistant protozoal infections | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-06-06 | — | — | EP | disclosed |
| EP-0303961-A2 | Novel antidepressants | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-02-22 | — | — | EP | disclosed |