Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.55 |
| ▸ | CTSB | P07858 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.46 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29708012 | 0.83 | TDP1 (0.57) | TDP1CTSBALDH1A1NCOA1NCOA3 | |
| SCHEMBL2030842 | 0.83 | TDP1 (0.57) | TDP1CTSBALDH1A1NCOA1NCOA3 | |
| SCHEMBL7788656 | 0.82 | TDP1 (0.80) | TDP1CTSBALDH1A1NCOA1NCOA3 | |
| SCHEMBL131220 | 0.76 | MAPT (0.55) | TDP1ALDH1A1HSD17B10MAPTSMN1; SMN2 | |
| SCHEMBL9839023 | 0.73 | TDP1 (0.72) | TDP1CTSBALDH1A1NCOA1NCOA3 | |
| SCHEMBL9839029 | 0.73 | TDP1 (0.72) | TDP1CTSBALDH1A1NCOA1NCOA3 | |
| SCHEMBL29475175 | 0.73 | TDP1 (1.00) | TDP1CTSBALDH1A1NCOA1NCOA3 | |
| SCHEMBL57166 | 0.73 | TDP1 (1.00) | TDP1CTSBALDH1A1NCOA1NCOA3 | |
| SCHEMBL1394957 | 0.72 | TDP1 (0.69) | TDP1CTSBALDH1A1NCOA1NCOA3 | |
| SCHEMBL8153134 | 0.71 | ALDH1A1 (0.55) | TDP1CTSBALDH1A1HPRT1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944594-A4 | INHIBITORS OF THE ENZYMATIC ACTIVITY OF PSA | LILLY CO ELI (US) | 2000-05-03 | — | — | EP | disclosed |
| EP-0944594-A1 | INHIBITORS OF THE ENZYMATIC ACTIVITY OF PSA | ELI LILLY AND COMPANY (US) | 1999-09-29 | — | — | EP | disclosed |
| WO-1998025895-A1 | INHIBITORS OF THE ENZYMATIC ACTIVITY OF PSA | ELI LILLY AND COMPANY (US) | 1998-06-18 | — | — | WO | disclosed |