Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | XBP1 | P17861 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8151548 | 0.91 | HTR2A (0.47) | BLMTSHRHTR2AHRH1SLC6A2 | |
| SCHEMBL8151546 | 0.91 | HTR2A (0.47) | BLMTSHRHTR2AHRH1SLC6A2 | |
| SCHEMBL8159534 | 0.91 | HTR2A (0.47) | BLMTSHRHTR2AHRH1SLC6A2 | |
| SCHEMBL8151545 | 0.91 | HTR2A (0.47) | BLMTSHRHTR2AHRH1SLC6A2 | |
| SCHEMBL8159528 | 0.91 | HTR2A (0.47) | BLMTSHRHTR2AHRH1SLC6A2 | |
| SCHEMBL7305028 | 0.81 | BLM (0.51) | BLMTSHRALDH1A1HTTXBP1 | |
| SCHEMBL8158561 | 0.81 | SLC6A2 (0.54) | BLMTSHRALDH1A1HTR2AHRH1 | |
| SCHEMBL12362873 | 0.81 | SLC6A2 (0.54) | BLMTSHRALDH1A1HTR2AHRH1 | |
| SCHEMBL8152258 | 0.81 | SLC6A2 (0.54) | BLMTSHRALDH1A1HTR2AHRH1 | |
| SCHEMBL8152263 | 0.81 | SLC6A2 (0.54) | BLMTSHRALDH1A1HTR2AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6136803-A | CYCLOALKYL ETHER INDANAMINE COMPOUNDS | MERRELL PHARMACEUTICALS INC. (US) | 2000-10-24 | — | — | US | disclosed |
| EP-0303961-B1 | Novel antidepressants | MERRELL DOW PHARMA (US) | 1994-04-13 | — | — | EP | disclosed |
| EP-0371508-B1 | PHENOXY AND PHENYLTHIO, AMINO SUBSTITUTED BENZOCYCLOALKANE DERIVATIVES IN THE TREATMENT AND PREVENTION OF DRUG-RESISTANT PROTOZOAL INFECTIONS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-07-14 | — | — | EP | disclosed |
| US-5134168-A | PHENOXY AND PHENYLTHIO, AMINO SUBSTITUTED BENZOCYCLOALKANE DERIVATIVES IN THE TREATMENT AND PREVENTION OF DRUG-RESISTANT PROTOZOAL INFECTIONS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-07-28 | — | — | US | disclosed |
| EP-0371508-A1 | Phenoxy and phenylthio, amino substituted benzocycloalkane derivatives in the treatment and prevention of drug-resistant protozoal infections | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-06-06 | — | — | EP | disclosed |
| EP-0303961-A2 | Novel antidepressants | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-02-22 | — | — | EP | disclosed |