Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 18/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 18/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 17/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8171793 | 0.88 | PIK3CA (0.54) | PIK3CBPIK3CDPIK3CAPIK3CGMTOR | |
| SCHEMBL8160997 | 0.78 | PRKDC (0.64) | PIK3CBPIK3CDPIK3CAMTORPRKDC | |
| SCHEMBL13435574 | 0.75 | PRKDC (0.66) | PIK3CBPIK3CDPIK3CAPIK3CGMTOR | |
| SCHEMBL13752231 | 0.69 | PIK3CD (0.69) | PIK3CBPIK3CDPIK3CAMTORPRKDC | |
| SCHEMBL13597272 | 0.67 | KDM4E (0.45) | — | |
| SCHEMBL15176604 | 0.67 | PIK3CD (0.46) | PIK3CBPIK3CDPIK3CAPRKDC | |
| SCHEMBL15174417 | 0.65 | PIK3CB (0.53) | PIK3CBPIK3CDPIK3CAPRKDC | |
| SCHEMBL11634420 | 0.64 | ADORA2A (0.37) | — | |
| SCHEMBL13403480 | 0.64 | PRKDC (0.64) | PIK3CBPIK3CDPIK3CAMTORPRKDC | |
| SCHEMBL13910529 | 0.63 | GSK3B (0.66) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008148074-A2 | INHIBITORS OF MTOR AND METHODS OF TREATMENT USING SAME | RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2008-12-04 | — | — | WO | disclosed |