Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 2/20 | 0.64 |
| ▸ | MTOR | P42345 | 1/20 | 0.64 |
| ▸ | PIK3CD | O00329 | 17/20 | 0.64 |
| ▸ | PIK3CB | P42338 | 17/20 | 0.64 |
| ▸ | PIK3CA | P42336 | 16/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13403480 | 0.84 | PRKDC (0.64) | PRKDCMTORPIK3CDPIK3CBPIK3CA | |
| SCHEMBL13752231 | 0.84 | PIK3CD (0.69) | PRKDCMTORPIK3CDPIK3CBPIK3CA | |
| SCHEMBL13752230 | 0.81 | PRKDC (0.64) | PRKDCMTORPIK3CDPIK3CBPIK3CA | |
| SCHEMBL8171793 | 0.80 | PIK3CA (0.54) | PRKDCMTORPIK3CDPIK3CBPIK3CA | |
| SCHEMBL910160 | 0.79 | PIK3CB (0.73) | PRKDCMTORPIK3CDPIK3CBPIK3CA | |
| SCHEMBL13752195 | 0.78 | PIK3CD (0.69) | PRKDCMTORPIK3CDPIK3CBPIK3CA | |
| SCHEMBL8159976 | 0.78 | PIK3CB (0.45) | PRKDCMTORPIK3CDPIK3CBPIK3CA | |
| SCHEMBL24713645 | 0.78 | PRKDC (0.53) | PRKDCMTORPIK3CDPIK3CBPIK3CA | |
| SCHEMBL10092321 | 0.78 | PRKDC (1.00) | PRKDCMTORPIK3CDPIK3CBPIK3CA | |
| SCHEMBL4544196 | 0.77 | PRKDC (1.00) | PRKDCMTORPIK3CDPIK3CBPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008148074-A2 | INHIBITORS OF MTOR AND METHODS OF TREATMENT USING SAME | RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2008-12-04 | — | — | WO | disclosed |