Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 3/20 | 0.57 |
| ▸ | CES1 | P23141 | 3/20 | 0.57 |
| ▸ | ERCC5 | P28715 | 2/20 | 0.42 |
| ▸ | FEN1 | P39748 | 2/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.36 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.33 |
| ▸ | FABP4 | P15090 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8165593 | 0.83 | ERCC5 (0.40) | CES2CES1ERCC5FEN1PTPN1 | |
| SCHEMBL10539615 | 0.83 | SMN1; SMN2 (0.40) | CES2CES1ERCC5FEN1PTPN1 | |
| SCHEMBL8945742 | 0.82 | CES2 (0.55) | CES2CES1ERCC5FEN1PTPN1 | |
| SCHEMBL6623875 | 0.81 | CES2 (0.53) | CES2CES1ALDH1A1KDM4EKMT2A | |
| SCHEMBL8927304 | 0.80 | PTPN1 (0.37) | CES2CES1ERCC5FEN1PTPN1 | |
| SCHEMBL30194898 | 0.80 | PTPN1 (0.38) | CES2CES1ERCC5FEN1PTPN1 | |
| SCHEMBL1187294 | 0.80 | PTPN1 (0.38) | CES2CES1ERCC5FEN1PTPN1 | |
| SCHEMBL2373430 | 0.78 | CES2 (0.59) | CES2CES1ALDH1A1BCHEKDM4E | |
| SCHEMBL9612851 | 0.78 | CES2 (0.59) | CES2CES1ALDH1A1BCHEHTT | |
| SCHEMBL241797 | 0.76 | CES2 (0.70) | CES2CES1ALDH1A1MAP2K1MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2822945-B1 | AMINOMETHYLENE PYRAZOLONES WITH THERAPEUTIC ACTIVITY | COMPOUND HANDLING B V (NL) | 2019-06-19 | — | — | EP | disclosed |
| US-10071987-B2 | Aminomethylene pyrazolones with therapeutic activity | COMPOUND HANDLING B.V. (NL) | 2018-09-11 | — | — | US | disclosed |
| US-20180030035-A1 | AMINOMETHYLENE PYRAZOLONES WITH THERAPEUTIC ACTIVITY | COMPOUND HANDLING B.V. (NL) | 2018-02-01 | — | — | US | disclosed |
| US-9790205-B2 | Aminomethylene pyrazolones with therapeutic activity | COMPOUND HANDLING B.V. (NL) | 2017-10-17 | — | — | US | disclosed |
| US-20170240531-A1 | AMINOMETHYLENE PYRAZOLONES WITH THERAPEUTIC ACTIVITY | COMPOUND HANDLING B.V. (NL) | 2017-08-24 | — | — | US | disclosed |
| US-9676764-B2 | Aminomethylene pyrazolones with therapeutic activity | COMPOUND HANDLING B.V. (NL) | 2017-06-13 | — | — | US | disclosed |
| US-20160326152-A1 | AMINOMETHYLENE PYRAZOLONES WITH THERAPEUTIC ACTIVITY | COMPOUND HANDLING B.V. (NL) | 2016-11-10 | — | — | US | disclosed |
| US-9453012-B2 | Aminomethylene pyrazolones with therapeutic activity | COMPOUND HANDLING B.V. (NL) | 2016-09-27 | — | — | US | disclosed |
| US-20150073019-A1 | AMINOMETHYLENE PYRAZOLONES WITH THERAPEUTIC ACTIVITY | SPECS COMPOUND HANDLING B.V. (NL) | 2015-03-12 | — | — | US | disclosed |
| EP-2822945-A1 | AMINOMETHYLENE PYRAZOLONES WITH THERAPEUTIC ACTIVITY | Compound Handling B.V. (NL) | 2015-01-14 | — | — | EP | disclosed |
| WO-2013131931-A1 | AMINOMETHYLENE PYRAZOLONES WITH THERAPEUTIC ACTIVITY | COMPOUND HANDLING B.V. (NL) | 2013-09-12 | — | — | WO | disclosed |
| US-6114590-A | Process for the preparation of polyhalogenated benzotrifluorides, benzotrichlorides and benzoyl chlorides and new trihalogenobenzotrichlorides and -benzoyl chlorides | BAYER AKTIENGESELLSCHAFT (DE) | 2000-09-05 | — | — | US | disclosed |
| US-6075165-A | Process for the preparation of polyhalogenated benzotrifluorides, benzotrichlorides and benzoyl chlorides and new trihalogenobenzotrichlorides and -benzoyl chlorides | BAYER AKTIENGESELLSCHAFT (DE) | 2000-06-13 | — | — | US | disclosed |
| US-5599980-A | Process for the preparation of polyhalogenated benzotrifluorides, benzotrichlorides and benzoyl chlorides and new trihalogenobenzotrichlorides and -benzoyl chlorides | BAYER AKTIENGESELLSCHAFT (DE) | 1997-02-04 | — | — | US | disclosed |
| US-5457104-A | Antibacterials | BAYER AKTIENGESELLSCHAFT (DE) | 1995-10-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.