Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.69 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.69 |
| ▸ | CDK2 | P24941 | 3/20 | 0.69 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.69 |
| ▸ | CDK4 | P11802 | 2/20 | 0.69 |
| ▸ | CCND1 | P24385 | 2/20 | 0.69 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.69 |
| ▸ | PRKCA | P17252 | 1/20 | 0.67 |
| ▸ | PRKACA | P17612 | 1/20 | 0.67 |
| ▸ | PRKACG | P22612 | 1/20 | 0.67 |
| ▸ | PRKACB | P22694 | 1/20 | 0.67 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.63 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.63 |
| ▸ | CDK9 | P50750 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30319793 | 0.93 | PIM1 (0.73) | PIM1CAMK2DCDK2CCNE2CDK4 | |
| SCHEMBL5688241 | 0.93 | PIM1 (0.73) | PIM1CAMK2DCDK2CCNE2CDK4 | |
| SCHEMBL8161268 | 0.92 | CCNT1 (0.75) | PIM1CAMK2DCDK2CCNE2CDK4 | |
| SCHEMBL8154274 | 0.89 | PIM1 (0.71) | PIM1CAMK2DCDK2CCNE2CDK4 | |
| SCHEMBL30834686 | 0.89 | CCNE2 (0.71) | PIM1CAMK2DCDK2CCNE2CDK4 | |
| SCHEMBL8161877 | 0.87 | PRKACA (0.76) | PIM1CAMK2DCDK2CCNE2CDK4 | |
| SCHEMBL8161831 | 0.87 | CCNT1 (0.64) | PIM1CAMK2DCDK2PRKCAPRKACA | |
| SCHEMBL8161322 | 0.86 | CCNE2 (0.74) | PIM1CAMK2DCDK2CCNE2CDK4 | |
| Hydrochloric Acid SCHEMBL8163206 | 0.86 | PIM1 (0.86) | PIM1CAMK2DCDK2CCNE2CDK4 | |
| SCHEMBL30319767 | 0.86 | PIM1 (0.77) | PIM1CAMK2DCDK2CCNE2CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE36736-E | Substituted pyrroles | HOFFMAN-LA ROCHE INC. (US) | 2000-06-13 | — | — | US | disclosed |
| EP-0674632-A1 | AMINOACID DERIVATIVES OF HETEROCYCLES AS PROTEIN KINASE C INHIBITORS | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994014798-A1 | AMINOACID DERIVATIVES OF HETEROCYCLES AS PROTEIN KINASE C INHIBITORS | Gödecke Aktiengesellschaft (DE) | 1994-07-07 | — | — | WO | disclosed |
| EP-0328026-B1 | SUBSTITUTED PYRROLES | F. HOFFMANN-LA ROCHE AG (CH) | 1993-04-28 | — | — | EP | disclosed |
| US-5057614-A | Antiinflammatory, immunology, bronchodilator agents, cardiovascular disorders | HOFFMANN-LA ROCHE INC. (US) | 1991-10-15 | — | — | US | disclosed |
| EP-0328026-A1 | Substituted pyrroles | F. HOFFMANN-LA ROCHE AG (CH) | 1989-08-16 | — | — | EP | disclosed |